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Diabetes mellitus i...
Diabetes mellitus in dog - : No evidence for a type-1-like phenotype
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- Ahlgren, Kerstin. M (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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Fall, Tove (författare)
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Landegren, Nils (författare)
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von Euler, Henrik (författare)
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Sundberg, Katarina (författare)
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Lindblad-Toh, Kerstin (författare)
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Lobell, Anna (författare)
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Hedhammar, Åke (författare)
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Andersson, Göran (författare)
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Hansson-Hamlin, Helene (författare)
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Lernmark, Åke (författare)
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Kämpe, Olle (författare)
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(creator_code:org_t)
- Engelska.
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Aims/hypothesis Diabetes mellitus (DM) is one of the most common endocrine disorders in dogs, and is commonly proposed to be of autoimmune origin. Although the clinical symptoms of human type 1 diabetes (T1D) and canine DM are similar, the aetiologies may differ. The aim of this study was to investigate if autoimmune aetiology resembling human T1D is as prevalent in dogs as previously reported. Methods Sera from 121 diabetic dogs representing 38 different breeds were tested for islet cell antibodies (ICA) and GAD65 autoantibodies (GADA) and compared with sera from 133 healthy dogs from 40 breeds. ICA was detected by indirect immunofluorescence using both canine and human frozen sections. GADA was detected by in vitro transcription and translation (ITT) of human and canine GAD65, followed by immunoprecipitation. Results None of the canine sera analyzed tested positive for ICA on sections of frozen canine or human ICA pancreas. However, serum from one diabetic dog was weakly positive in the canine GADA assay and serum from one healthy dog was weakly positive in the human GADA assay. Conclusions/interpretations Based on sera from 121 diabetic dogs from 38 different breeds were tested for humoral autoreactivity using four different assays, contrary to previous observations, we find no support for an autoimmune aetiology in canine diabetes.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Nyckelord
- Autoimmunity
- autoantibodies
- canine
- diabetes mellitus
- GAD65
- ICA
- Medicin
- Medicine
Publikations- och innehållstyp
- vet (ämneskategori)
- ovr (ämneskategori)
- Av författaren/redakt...
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Ahlgren, Kerstin ...
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Fall, Tove
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Landegren, Nils
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von Euler, Henri ...
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Sundberg, Katari ...
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Lindblad-Toh, Ke ...
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visa fler...
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Lobell, Anna
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Hedhammar, Åke
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Andersson, Göran
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Hansson-Hamlin, ...
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Lernmark, Åke
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Kämpe, Olle
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Immunologi
- Av lärosätet
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Uppsala universitet