Sökning: onr:"swepub:oai:DiVA.org:uu-161054" > Effects of the Circ...
Fältnamn | Indikatorer | Metadata |
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000 | 04137naa a2200553 4500 | |
001 | oai:DiVA.org:uu-161054 | |
003 | SwePub | |
008 | 111107s2011 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1610542 URI |
024 | 7 | a https://doi.org/10.1176/appi.ajp.2011.101115792 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Dong, Li4 aut |
245 | 1 0 | a Effects of the Circadian Rhythm Gene Period 1 (Per1) on Psychosocial Stress-Induced Alcohol Drinking |
264 | 1 | b American Psychiatric Association Publishing,c 2011 |
338 | a print2 rdacarrier | |
520 | a Objective: Circadian and stress-response systems mediate environmental changes that affect alcohol drinking. Psychosocial stress is an environmental risk factor for alcohol abuse. Circadian rhythm gene period 1(Per1) is targeted by stress hormones and is transcriptionally activated in corticotropin releasing factor-expressing cells. The authors hypothesized that Per1 is involved in integrating stress response and circadian rhythmicity and explored its relevance to alcohol drinking. Method: In mice, the effects of stress on ethanol intake in mPer1-mutant and wild-type mice were assessed. In humans, single nucleotide polymorphisms (SNPs) in hPer1 were tested for association with alcohol drinking behavior in 273 adolescents and an adult case-control sample of 1,006 alcohol-dependent patients and 1,178 comparison subjects. In vitro experiments were conducted to measure genotype-specific expression and transcription factor binding to hPer1. Results: The mPer1-mutant mice showed enhanced alcohol consumption in response to social defeat stress relative to their wild-type littermates. An association with the frequency of heavy drinking in adolescents with the hPer1 promoter SNP rs3027172 and with psychosocial adversity was found. There was significant interaction between the rs3027172 genotype and psychosocial adversity on this drinking measure. In a confirmatory analysis, association of hPer1 rs3027172 with alcohol dependence was shown. Cortisol-induced transcriptional activation of hPer1 was reduced in human B-lymphoblastoid cells carrying the risk genotype of rs3027172. Binding affinity of the transcription factor Snail1 to the risk allele of the hPer1 SNP rs3027172 was also reduced. Conclusions: The findings indicate that the hPer1 gene regulates alcohol drinking behavior during stressful conditions and provide evidence for underlying neurobiological mechanisms. | |
700 | 1 | a Bilbao, Ainhoa4 aut |
700 | 1 | a Laucht, Manfred4 aut |
700 | 1 | a Henriksson, Richard4 aut |
700 | 1 | a Yakovleva, Tatjanau Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)tatia678 |
700 | 1 | a Ridinger, Monika4 aut |
700 | 1 | a Desrivieres, Sylvane4 aut |
700 | 1 | a Clarke, Toni-Kim4 aut |
700 | 1 | a Lourdusamy, Anbarasu4 aut |
700 | 1 | a Smolka, Michael N.4 aut |
700 | 1 | a Cichon, Sven4 aut |
700 | 1 | a Blomeyer, Dorothea4 aut |
700 | 1 | a Treutlein, Jens4 aut |
700 | 1 | a Perreau-Lenz, Stephanie4 aut |
700 | 1 | a Witt, Stephanie4 aut |
700 | 1 | a Leonardi-Essmann, Fernando4 aut |
700 | 1 | a Wodarz, Norbert4 aut |
700 | 1 | a Zill, Peter4 aut |
700 | 1 | a Soyka, Michael4 aut |
700 | 1 | a Albrecht, Urs4 aut |
700 | 1 | a Rietschel, Marcella4 aut |
700 | 1 | a Lathrop, Mark4 aut |
700 | 1 | a Bakalkin, Georgyu Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)gueba200 |
700 | 1 | a Spanagel, Rainer4 aut |
700 | 1 | a Schumann, Gunter4 aut |
710 | 2 | a Uppsala universitetb Institutionen för farmaceutisk biovetenskap4 org |
773 | 0 | t American Journal of Psychiatryd : American Psychiatric Association Publishingg 168:10, s. 1090-1098q 168:10<1090-1098x 0002-953Xx 1535-7228 |
856 | 4 | u http://doc.rero.ch/record/27113/files/alb_ecr.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-161054 |
856 | 4 8 | u https://doi.org/10.1176/appi.ajp.2011.10111579 |
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