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Biomarkers of disea...
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Kultima, KimUppsala universitet,Cancerfarmakologi och beräkningsmedicin,Analytisk kemi,Cancer Pharmacology and Computational Medicine
(författare)
Biomarkers of disease and post-mortem changes : Heat stabilization, a necessary tool for measurement of protein regulation
- Artikel/kapitelEngelska2011
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Elsevier BV,2011
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LIBRIS-ID:oai:DiVA.org:uu-163496
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-163496URI
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https://doi.org/10.1016/j.jprot.2011.06.009DOI
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Språk:engelska
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Sammanfattning på:engelska
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Första-, andra- och tredjeförfattare delar författarskapet.
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This review focuses on post sampling changes and how the Stabilizor system has been used to control this natural biological process and potential implications on cancer-specific biomarkers due to post sampling changes. Tissue sampling is a major traumatic event that can have drastic effects within a very short timeframe at the molecular level [1] resulting in loss of sample quality due to post-mortem changes. A heat-stabilization technology, using the Stabilizor system, has been developed to quickly and permanently abolish the enzymatic activity that causes these changes post-sampling and so preserve sample quality. The Stabilizor system has been shown to give better sample quality when analyzing a variety of tissues in various proteomic workflows. In this paper we discuss the impact of using heat-stabilized tissue in different proteomic applications. Based on our observations regarding the overlap between commonly changing proteins and proteins found to change post-mortem we also highlight a group of proteins of particular interest in cancer studies.
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Sköld, Karl
(författare)
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Borén, Mats
(författare)
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Uppsala universitetCancerfarmakologi och beräkningsmedicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Proteomics: Elsevier BV75:1, s. 145-1591874-39191876-7737
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