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Serum fatty-acid co...
Serum fatty-acid composition and the risk of Alzheimer’s disease : a longitudinal population based study
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- Rönnemaa, Elina, 1975- (författare)
- Uppsala universitet,Geriatrik
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- Zethelius, Björn (författare)
- Uppsala universitet,Geriatrik
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- Vessby, Bengt (författare)
- Uppsala universitet,Geriatrik
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- Lannfelt, Lars (författare)
- Uppsala universitet,Geriatrik,Molekylär geriatrik
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- Byberg, Liisa (författare)
- Uppsala universitet,Ortopedi
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- Kilander, Lena (författare)
- Uppsala universitet,Geriatrik
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(creator_code:org_t)
- 2012-06-20
- 2012
- Engelska.
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Ingår i: European Journal of Clinical Nutrition. - : Springer Science and Business Media LLC. - 0954-3007 .- 1476-5640. ; 66:8, s. 885-890
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- BACKGROUND/OBJECTIVES:It is unknown if a specific fatty-acid composition influences the development of Alzheimer's disease (AD). Nutrition is a possible target for prevention of dementia and especially omega-3-based fatty acids (n-3 FAs) have previously been suggested to be beneficial for cognition. The objective was to ascertain whether serum FAs predicts the risk of incident AD and dementia in a longitudinal population-based cohort.SUBJECTS/METHODS:Uppsala Longitudinal Study of Adult Men started in 1970. The proportions of FAs in serum cholesteryl esters were estimated in men (n=2009) who were 50 years old at baseline. During a 35 year follow-up time, 213 men had developed dementia, out of which 91 AD. The associations were analyzed with Cox proportional hazards and logistic regression; adjusted for age, education and vascular risk factors.RESULTS:Subjects with a higher proportion of saturated FAs had a decreased risk of AD in crude and multi-adjusted models (hazard ratio for 1-s.d. increase in palmitic acid 0.72; 95% confidence intervals: 0.59-0.89). These associations persisted even in the group of approximately 85-year-old survivors. n-3 FAs FAs were not associated with decreased risk of AD or dementia.CONCLUSIONS:In contrast to experimental studies, saturated FAs were inversely associated with risk of AD. No evidence of a protective effect of n-3 FAs against dementia was found. The results remained essentially unchanged if competing risk from mortality was taken into account.
Nyckelord
- fatty acid
- alzheimer's disease
- dementia
- Geriatrics
- Geriatrik
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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