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Decreased blood los...
Decreased blood loss after cardiopulmonary bypass using heparin-coated circuit and 50% reduction of heparin dose
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- Borowiec, Jan (författare)
- Uppsala universitet,Thoraxkirurgi
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- Thelin, Stefan (författare)
- Uppsala universitet,Thoraxkirurgi
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Bagge, L (författare)
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visa fler...
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Hultman, J (författare)
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Hansson, H E (författare)
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visa färre...
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(creator_code:org_t)
- 1992
- 1992
- Engelska.
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Ingår i: Scandinavian journal of thoracic and cardiovascular surgery. - 0036-5580. ; 26:3, s. 177-185
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
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- In a randomized, double-blind study of patients undergoing elective coronary artery grafting, the effect of heparin-coated circuit combined with 50% reduction of systemic heparin bolus was investigated. Ten patients comprised group HC (heparin-coated) and ten group C (controls). The mean total doses of heparin were 172 IU/kg in group HC and 416 IU/kg in group C and the respective protamine doses were 0.96 and 3.96 mg/kg (both p < 0.001). Activated clotting times during cardiopulmonary bypass were significantly shorter in group HC, and both intra- and postoperative bleeding was significantly less than in group C (7.7 vs. 11.7 ml/kg, p = 0.036, and 6.9 vs. 9.7 ml/kg, p = 0.004). Hemoglobin loss via the drains was 22.5 g in group HC and 43.7 g in group C (p < 0.005). Hemolysis at the end of bypass was significantly greater in group C. Apart from one perioperative myocardial infarction in group HC the postoperative course was uneventful. Use of a heparin-coated circuit is concluded to permit complication-free reduction of heparin and protamine doses and to decrease both intra- and postoperative bleeding, which may favorably influence the outcome of coronary artery grafting.
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