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Angiographic outcom...
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Morice, Marie-Claude
(författare)
Angiographic outcomes following stenting or coronary artery bypass surgery of the left main coronary artery : fifteen-month outcomes from the synergy between PCI with TAXUS express and cardiac surgery left main angiographic substudy (SYNTAX-LE MANS)
- Artikel/kapitelEngelska2011
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LIBRIS-ID:oai:DiVA.org:uu-165406
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-165406URI
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https://doi.org/10.4244/EIJV7I6A109DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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AIMS: The SYNTAX-LE MANS substudy prospectively evaluated 15-month angiographic and clinical outcomes in patients with treated left main (LM) disease. METHODS AND RESULTS: In the SYNTAX trial, 1,800 patients with three-vessel and/or LM disease were randomised to either CABG or PCI; of these, 271 LM patients were prospectively assigned to receive a 15-month angiogram. The primary endpoint for the CABG arm was the ratio of ≥50% to <100% obstructed/occluded grafts bypassing LM lesions to the number placed. The primary endpoint for the PCI arm was the proportion of patients with ≤50% diameter stenosis ('patent' stents) of treated LM lesions. Per protocol, no formal comparison between CABG and PCI arms was intended based on the differing primary endpoints. Available 15-month angiograms were analysed for 114 CABG and 149 PCI patients. At 15 months, 9.9% (26/263) of CABG grafts were 100% occluded and an additional 5.7% (15/263) were ≥50% to <100% occluded. Overall, 27.2% (31/114) of patients had ≥1 obstructed/occluded graft. The 15-month CABG MACCE rate was 8.8% (10/114) and MACCE at 15 months was not significantly associated with graft obstruction/occlusion (p=0.85). In the PCI arm, 92.4% (134/145) of patients had ≤50% diameter LM stenosis at 15 months (89.7% [87/97] distal LM lesions and 97.9% [47/48] non-distal LM lesions). The 15-month PCI MACCE rate was 12.8% (20/156) and this was significantly associated with lack of stent patency at 15 months (p<0.001), mainly due to repeat revascularisation. CONCLUSIONS: At 15 months, 15.6% (41/263) of grafts were at least 50% obstructed but this was not significantly associated with MACCE; 92.4% (134/145) of patients had stents that remained patent at 15 months, and stent restenosis was significantly associated with MACCE, predominantly due to revascularisation.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Feldman, Ted E E
(författare)
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Mack, Michael J
(författare)
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Ståhle, ElisabethUppsala universitet,Thoraxkirurgi(Swepub:uu)elsta102
(författare)
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Holmes, David R
(författare)
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Colombo, Antonio
(författare)
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Morel, Marie-Angèle
(författare)
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van den Brand, Marcel
(författare)
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Serruys, Patrick W
(författare)
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Mohr, Friedrich
(författare)
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Carrié, Didier
(författare)
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Fournial, Gérard
(författare)
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James, Stefan,1964-Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)stjam367
(författare)
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Leadley, Katrin
(författare)
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Dawkins, Keith D
(författare)
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Kappetein, A Pieter
(författare)
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Uppsala universitetThoraxkirurgi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology7:6, s. 670-6791969-6213
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Morice, Marie-Cl ...
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Feldman, Ted E E
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Mack, Michael J
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Ståhle, Elisabet ...
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Holmes, David R
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Colombo, Antonio
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visa fler...
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Morel, Marie-Ang ...
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van den Brand, M ...
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Serruys, Patrick ...
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Mohr, Friedrich
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Carrié, Didier
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Fournial, Gérard
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James, Stefan, 1 ...
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Leadley, Katrin
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Dawkins, Keith D
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Kappetein, A Pie ...
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visa färre...
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och Klinisk medicin
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