Sökning: onr:"swepub:oai:DiVA.org:uu-167672" >
beta-Cell Loss and ...
beta-Cell Loss and beta-Cell Apoptosis in Human Type 2 Diabetes Are Related to Islet Amyloid Deposition
-
Jurgens, Catherine A. (författare)
-
Toukatly, Mirna N. (författare)
-
Fligner, Corinne L. (författare)
-
visa fler...
-
Udayasankar, Jayalakshmi (författare)
-
Subramanian, Shoba L. (författare)
-
Zraika, Sakeneh (författare)
-
Aston-Mourney, Kathryn (författare)
-
Carr, Darcy B. (författare)
-
- Westermark, Per (författare)
- Uppsala universitet,Molekylär och morfologisk patologi
-
- Westermark, Gunilla T. (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
-
Kahn, Steven E. (författare)
-
Hull, Rebecca L. (författare)
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- Engelska.
-
Ingår i: American Journal of Pathology. - : Elsevier BV. - 0002-9440 .- 1525-2191. ; 178:6, s. 2632-2640
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Amyloid deposition and reduced beta-cell mass are pathological hallmarks of the pancreatic islet in type 2 diabetes; however, whether the extent of amyloid deposition is associated with decreased beta-cell mass is debated. We investigated the possible relationship and, for the first time, determined whether increased islet amyloid and/or decreased beta-cell area quantified on histological sections is correlated with increased beta-cell apoptosis. Formalin-fixed, paraffin-embedded human pancreas sections from subjects with (n = 29) and without (n = 39) diabetes were obtained at autopsy (64 +/- 2 and 70 +/- 4 islets/subject, respectively). Amyloid and beta cells were visualized by thioflavin S and insulin inununolabeling. Apoptotic beta cells were detected by colabeling for insulin and by TUNEL. Diabetes was associated with increased amyloid deposition, decreased beta-cell area, and increased beta-cell apoptosis, as expected. There was a strong inverse correlation between beta-cell area and amyloid deposition (r = -0.42, P < 0.001). beta-Cell area was selectively reduced in individual amyloid-containing islets from diabetic subjects, compared with control subjects, but amyloid-free islets had beta-cell area equivalent to islets from control subjects. Increased amyloid 'deposition was associated with beta-cell apoptosis (r = 0.56, P < 0.01). Thus, islet amyloid is associated with decreased beta-cell area and increased beta-cell apoptosis, suggesting that islet amyloid deposition contributes to the decreased beta-cell mass that characterizes type 2 diabetes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Pathology
- Patologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Jurgens, Catheri ...
-
Toukatly, Mirna ...
-
Fligner, Corinne ...
-
Udayasankar, Jay ...
-
Subramanian, Sho ...
-
Zraika, Sakeneh
-
visa fler...
-
Aston-Mourney, K ...
-
Carr, Darcy B.
-
Westermark, Per
-
Westermark, Guni ...
-
Kahn, Steven E.
-
Hull, Rebecca L.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
- Artiklar i publikationen
-
American Journal ...
- Av lärosätet
-
Uppsala universitet