Sökning: onr:"swepub:oai:DiVA.org:uu-167672" >
beta-Cell Loss and ...
-
Jurgens, Catherine A.
(författare)
beta-Cell Loss and beta-Cell Apoptosis in Human Type 2 Diabetes Are Related to Islet Amyloid Deposition
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
-
Elsevier BV,2011
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-167672
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-167672URI
-
https://doi.org/10.1016/j.ajpath.2011.02.036DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Title also written as: β-cell loss and β-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition
-
Amyloid deposition and reduced beta-cell mass are pathological hallmarks of the pancreatic islet in type 2 diabetes; however, whether the extent of amyloid deposition is associated with decreased beta-cell mass is debated. We investigated the possible relationship and, for the first time, determined whether increased islet amyloid and/or decreased beta-cell area quantified on histological sections is correlated with increased beta-cell apoptosis. Formalin-fixed, paraffin-embedded human pancreas sections from subjects with (n = 29) and without (n = 39) diabetes were obtained at autopsy (64 +/- 2 and 70 +/- 4 islets/subject, respectively). Amyloid and beta cells were visualized by thioflavin S and insulin inununolabeling. Apoptotic beta cells were detected by colabeling for insulin and by TUNEL. Diabetes was associated with increased amyloid deposition, decreased beta-cell area, and increased beta-cell apoptosis, as expected. There was a strong inverse correlation between beta-cell area and amyloid deposition (r = -0.42, P < 0.001). beta-Cell area was selectively reduced in individual amyloid-containing islets from diabetic subjects, compared with control subjects, but amyloid-free islets had beta-cell area equivalent to islets from control subjects. Increased amyloid 'deposition was associated with beta-cell apoptosis (r = 0.56, P < 0.01). Thus, islet amyloid is associated with decreased beta-cell area and increased beta-cell apoptosis, suggesting that islet amyloid deposition contributes to the decreased beta-cell mass that characterizes type 2 diabetes.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Toukatly, Mirna N.
(författare)
-
Fligner, Corinne L.
(författare)
-
Udayasankar, Jayalakshmi
(författare)
-
Subramanian, Shoba L.
(författare)
-
Zraika, Sakeneh
(författare)
-
Aston-Mourney, Kathryn
(författare)
-
Carr, Darcy B.
(författare)
-
Westermark, PerUppsala universitet,Molekylär och morfologisk patologi(Swepub:uu)perweste
(författare)
-
Westermark, Gunilla T.Uppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)gunwe105
(författare)
-
Kahn, Steven E.
(författare)
-
Hull, Rebecca L.
(författare)
-
Uppsala universitetMolekylär och morfologisk patologi
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:American Journal of Pathology: Elsevier BV178:6, s. 2632-26400002-94401525-2191
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Jurgens, Catheri ...
-
Toukatly, Mirna ...
-
Fligner, Corinne ...
-
Udayasankar, Jay ...
-
Subramanian, Sho ...
-
Zraika, Sakeneh
-
visa fler...
-
Aston-Mourney, K ...
-
Carr, Darcy B.
-
Westermark, Per
-
Westermark, Guni ...
-
Kahn, Steven E.
-
Hull, Rebecca L.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
- Artiklar i publikationen
-
American Journal ...
- Av lärosätet
-
Uppsala universitet