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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02674naa a2200337 4500 | |
| 001 | oai:DiVA.org:uu-168560 | |
| 003 | SwePub | |
| 008 | 120213s2012 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1685602 URI |
| 024 | 7 | a https://doi.org/10.1111/j.1365-3083.2011.02613.x2 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Nielsen, J. S.4 aut |
| 245 | 1 0 | a Rough-Form Lipopolysaccharide Increases Apoptosis in Human CD4+and CD8+T Lymphocytes |
| 264 | c 2012-01-10 | |
| 264 | 1 | b Wiley,c 2012 |
| 338 | a print2 rdacarrier | |
| 520 | a Immunosuppression induced by lymphocyte apoptosis is considered an important factor in the pathogenesis of sepsis and has been demonstrated in both animal models of lipopolysaccharide (LPS)-induced endotoxemia and septic patients. As rough-form LPS (R-LPS) has recently been shown to elicit a stronger immunological response than regular smooth-form LPS (S-LPS), we aimed to assess the apoptosis-inducing capabilities of R-LPS in different subsets of lymphocytes (CD4+ T cells, CD8+ T cell, B cells and NK cells). Using multicolour flow cytometry on human peripheral blood mononuclear cells, we found that R-LPS increased apoptosis in CD4+ and CD8+ T cells assessed by annexin V and propidium iodide (AV+PI-), compared with both S-LPS-stimulated and unstimulated cells. 7-Amino-actinomycin D and staining for intracellular active caspase-3, which are considered later signs of apoptosis, did not reveal the same results. Both forms appeared to inhibit apoptosis in B cells, but no LPS-form-specific effect was seen on B or NK cells. Our results indicate that R-LPS induces a stronger AV+PI--assessed apoptotic response in T cells than S-LPS. Our findings emphasize the importance of T cell apoptosis in endotoxemia and advocates for control of LPS form in both endotoxemia research and clinical trials with Gram-negative infections. | |
| 700 | 1 | a Larsson, Andersu Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)andla606 |
| 700 | 1 | a Ledet, T.4 aut |
| 700 | 1 | a Turina, M.4 aut |
| 700 | 1 | a Tonnesen, E.4 aut |
| 700 | 1 | a Krog, J.4 aut |
| 710 | 2 | a Uppsala universitetb Anestesiologi och intensivvård4 org |
| 773 | 0 | t Scandinavian Journal of Immunologyd : Wileyg 75:2, s. 193-202q 75:2<193-202x 0300-9475x 1365-3083 |
| 856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-3083.2011.02613.x |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-168560 |
| 856 | 4 8 | u https://doi.org/10.1111/j.1365-3083.2011.02613.x |
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