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Bioinformatic appro...
Bioinformatic approaches for modeling the substrate specificity of HIV-1 protease : an overview
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- Rögnvaldsson, Thorsteinn (författare)
- Högskolan i Halmstad,Halmstad Embedded and Intelligent Systems Research (EIS)
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- You, Liwen (författare)
- Lund University,Lunds universitet,Högskolan i Halmstad,Sektionen för Informationsvetenskap, Data– och Elektroteknik (IDE),Beräkningsbiologi och biologisk fysik - Genomgår omorganisation,Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation,Naturvetenskapliga fakulteten,Computational Biology and Biological Physics - Undergoing reorganization,Department of Astronomy and Theoretical Physics - Undergoing reorganization,Faculty of Science
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- Garwicz, Daniel (författare)
- Lund University,Lunds universitet,Uppsala universitet,Institutionen för medicinska vetenskaper,Inflammation,Karolinska Institutet, Department of Molecular Medicine and Surgery, Karolinska University Hospital, SE-17176, Stockholm, Sweden,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
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(creator_code:org_t)
- 2014-01-09
- 2007
- Engelska.
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Ingår i: Expert Review of Molecular Diagnostics. - : Informa UK Limited. - 1473-7159 .- 1744-8352. ; 7:4, s. 435-451
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Abstract
Ämnesord
Stäng
- HIV-1 protease has a broad and complex substrate specificity, which hitherto has escaped a simple comprehensive definition. This, and the relatively high mutation rate of the retroviral protease, makes it challenging to design effective protease inhibitors. Several attempts have been made during the last two decades to elucidate the enigmatic cleavage specificity of HIV-1 protease and to predict cleavage of novel substrates using bioinformatic analysis methods. This review describes the methods that have been utilized to date to address this important problem and the results achieved. The data sets used are also reviewed and important aspects of these are highlighted.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Computational Biology/*methods/*trends
- HIV-1/*enzymology
- Humans
- Models; Chemical
- Peptide Hydrolases/*chemistry/*metabolism
- Substrate Specificity/physiology
- MEDICINE
- MEDICIN
- protease
- prediction
- human immunodeficiency virus
- HIV
- bioinformatics
- cleavage rule
- physicochemical property
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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