Sökning: onr:"swepub:oai:DiVA.org:uu-169734" > A comprehensive ana...
Fältnamn | Indikatorer | Metadata |
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000 | 05007naa a2200721 4500 | |
001 | oai:DiVA.org:uu-169734 | |
003 | SwePub | |
008 | 120305s2012 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1697342 URI |
024 | 7 | a https://doi.org/10.1158/1078-0432.CCR-11-22102 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Schmidt, Marcus4 aut |
245 | 1 0 | a A comprehensive analysis of human gene expression profiles identifies stromal immunoglobulin kappa C as a compatible prognostic marker in human solid tumors |
264 | 1 | c 2012 |
338 | a print2 rdacarrier | |
520 | a PURPOSE:Although the central role of the immune system for tumor prognosis is generally accepted a single robust marker is not yet available.EXPERIMENTAL DESIGN:Based on ROC (receiver operating characteristic) analyses robust markers were identified from a 60 gene B-cell derived metagene and analyzed in gene expression profiles of 1810 breast cancer, 1056 non-small cell lung cancer, 513 colorectal and 426 ovarian cancer patients. Protein and RNA levels were examined in paraffin embedded tissue of 330 breast cancer patients. The cell types were identified using immunohistochemical co-staining and confocal fluorescence microscopy.RESULTS:We identified immunoglobulin kappa C (IGKC) which as a single marker is similarly predictive and prognostic as the entire B-cell metagene. IGKC was consistently associated with metastasis free survival across different molecular subtypes in node-negative breast cancer (n=965) and predicted response to anthracycline-based neoadjuvant chemotherapy (n=845) [P less than 0.001]. In addition, IGKC gene expression was prognostic in non-small cell lung cancer and colorectal cancer. No association was observed in ovarian cancer. IGKC protein expression was significantly associated with survival in paraffin embedded tissues of 330 breast cancer patients. Tumor infiltrating plasma cells were identified as the source of IGKC expressionCONCLUSION:Our findings provide IGKC as a novel diagnostic marker for risk stratification in human cancer and support concepts to exploit the humoral immune response for anti-cancer therapy. It could be validated in several independent cohorts and performed similarly well in RNA from fresh frozen as well as from paraffin tissue and on protein level by immunostaining. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng |
653 | a Patologi | |
653 | a Pathology | |
700 | 1 | a Hellwig, Birte4 aut |
700 | 1 | a Hammad, Seddik4 aut |
700 | 1 | a Othman, Amnah4 aut |
700 | 1 | a Lohr, Miriam4 aut |
700 | 1 | a Chen, Zonglin4 aut |
700 | 1 | a Böhm, Daniel4 aut |
700 | 1 | a Gebhard, Susanne4 aut |
700 | 1 | a Petry, Ilka Brigitte4 aut |
700 | 1 | a Lebrecht, Antje4 aut |
700 | 1 | a Cadenas, Cristina4 aut |
700 | 1 | a Marchan, Rosemarie4 aut |
700 | 1 | a Stewart, Joanna4 aut |
700 | 1 | a Solbach, Christine4 aut |
700 | 1 | a Holmberg, Larsu Uppsala universitet,Endokrinkirurgi,Regional Oncology Center4 aut0 (Swepub:uu)larsholmb |
700 | 1 | a Edlund, Karolinau Uppsala universitet,Molekylär och morfologisk patologi,Botling4 aut0 (Swepub:uu)kaedl086 |
700 | 1 | a Göransson Kultima, Hannau Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerfarmakologi och beräkningsmedicin4 aut0 (Swepub:uu)hagor102 |
700 | 1 | a Rody, Achim4 aut |
700 | 1 | a Berglund, Andersu Regional Oncology Center4 aut0 (Swepub:uu)andbe182 |
700 | 1 | a Lambe, Matsu Regional Oncology Center4 aut |
700 | 1 | a Isaksson, Andersu Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerfarmakologi och beräkningsmedicin4 aut0 (Swepub:uu)andeisak |
700 | 1 | a Botling, Johanu Uppsala universitet,Molekylär och morfologisk patologi,Botling4 aut0 (Swepub:uu)johanbot |
700 | 1 | a Karn, Thomas4 aut |
700 | 1 | a Müller, Volkmar4 aut |
700 | 1 | a Gerhold-Ay, Aslihan4 aut |
700 | 1 | a Cotarelo, Christina4 aut |
700 | 1 | a Sebastian, Martin4 aut |
700 | 1 | a Kronenwett, Ralf4 aut |
700 | 1 | a Bojar, Hans4 aut |
700 | 1 | a Lehr, Hans-Anton4 aut |
700 | 1 | a Sahin, Ugur4 aut |
700 | 1 | a Koelbl, Heinz4 aut |
700 | 1 | a Gehrmann, Mathias4 aut |
700 | 1 | a Micke, Patricku Uppsala universitet,Molekylär och morfologisk patologi,Botling4 aut0 (Swepub:uu)patmi676 |
700 | 1 | a Rahnenführer, Jörg4 aut |
700 | 1 | a Hengstler, Jan G4 aut |
710 | 2 | a Uppsala universitetb Endokrinkirurgi4 org |
773 | 0 | t Clinical Cancer Researchg 18:9, s. 2695-2703q 18:9<2695-2703x 1078-0432x 1557-3265 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-169734 |
856 | 4 8 | u https://doi.org/10.1158/1078-0432.CCR-11-2210 |
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