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Sökning: onr:"swepub:oai:DiVA.org:uu-171357" > Staging of neurofib...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004186naa a2200709 4500
001oai:DiVA.org:uu-171357
003SwePub
008120317s2008 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:117601588
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1713572 URI
0247 a https://doi.org/10.1111/j.1750-3639.2008.00147.x2 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1176015882 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Alafuzoff, Irinau Department of Neuroscience and Neurology, University of Kuopio Finland4 aut
2451 0a Staging of neurofibrillary pathology in Alzheimer's disease :b a study of the BrainNet Europe Consortium.
264 c 2008-03-27
264 1b Wiley,c 2008
338 a print2 rdacarrier
520 a It has been recognized that molecular classifications will form the basis for neuropathological diagnostic work in the future. Consequently, in order to reach a diagnosis of Alzheimer's disease (AD), the presence of hyperphosphorylated tau (HP-tau) and beta-amyloid protein in brain tissue must be unequivocal. In addition, the stepwise progression of pathology needs to be assessed. This paper deals exclusively with the regional assessment of AD-related HP-tau pathology. The objective was to provide straightforward instructions to aid in the assessment of AD-related immunohistochemically (IHC) detected HP-tau pathology and to test the concordance of assessments made by 25 independent evaluators. The assessment of progression in 7-microm-thick sections was based on assessment of IHC labeled HP-tau immunoreactive neuropil threads (NTs). Our results indicate that good agreement can be reached when the lesions are substantial, i.e., the lesions have reached isocortical structures (stage V-VI absolute agreement 91%), whereas when only mild subtle lesions were present the agreement was poorer (I-II absolute agreement 50%). Thus, in a research setting when the extent of lesions is mild, it is strongly recommended that the assessment of lesions should be carried out by at least two independent observers.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng
653 a Pathology
653 a Patologi
7001 a Arzberger, Thomas4 aut
7001 a Al-Sarraj, Safa4 aut
7001 a Bodi, Istvan4 aut
7001 a Bogdanovic, Nenadu Karolinska Institutet4 aut
7001 a Braak, Heiko4 aut
7001 a Bugiani, Orso4 aut
7001 a Del-Tredici, Kelly4 aut
7001 a Ferrer, Isidro4 aut
7001 a Gelpi, Ellen4 aut
7001 a Giaccone, Giorgio4 aut
7001 a Graeber, Manuel B4 aut
7001 a Ince, Paul4 aut
7001 a Kamphorst, Wouter4 aut
7001 a King, Andrew4 aut
7001 a Korkolopoulou, Penelope4 aut
7001 a Kovács, Gábor G4 aut
7001 a Larionov, Sergey4 aut
7001 a Meyronet, David4 aut
7001 a Monoranu, Camelia4 aut
7001 a Parchi, Piero4 aut
7001 a Patsouris, Efstratios4 aut
7001 a Roggendorf, Wolfgang4 aut
7001 a Seilhean, Danielle4 aut
7001 a Tagliavini, Fabrizio4 aut
7001 a Stadelmann, Christine4 aut
7001 a Streichenberger, Nathalie4 aut
7001 a Thal, Dietmar R4 aut
7001 a Wharton, Stephen B4 aut
7001 a Kretzschmar, Hans4 aut
7102 a Karolinska Institutetb Department of Neuroscience and Neurology, University of Kuopio Finland4 org
7730 t Brain Pathologyd : Wileyg 18:4, s. 484-96q 18:4<484-96x 1015-6305x 1750-3639
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1750-3639.2008.00147.x
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-171357
8564 8u https://doi.org/10.1111/j.1750-3639.2008.00147.x
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:117601588

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