On the role of the proform-conformation for processing and intracellular sorting of human cathepsin G.

Nyckelord

Animals

Anti-Bacterial Agents/pharmacology

Aprotinin/metabolism

Binding Sites

Biological Transport

Brefeldin A

COS Cells

Cathepsins/chemistry/*metabolism

Cyclopentanes/pharmacology

Cytoplasmic Granules/*metabolism

DNA; Complementary/genetics

Enzyme Precursors/chemistry/*metabolism

Glycosylation

Golgi Apparatus/drug effects

Hematopoietic Stem Cells/metabolism

Hexosaminidases/pharmacology

Humans

Leukemia; Basophilic; Acute/pathology

Macrolides

Mice

Mutagenesis; Site-Directed

Protein Conformation

Protein Folding

Protein Processing; Post-Translational

Rats

Recombinant Fusion Proteins/metabolism

Sequence Deletion

Serine Endopeptidases

Substrate Specificity

Transfection

Tumor Cells; Cultured

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)