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FGF1 containing bio...
FGF1 containing biodegradable device with peripheral nerve grafts induces corticospinal tract regeneration and motor evoked potentials after spinal cord resection
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- Nordblom, Jonathan (författare)
- Karolinska Institutet,Department of Clinical Neuroscience, KI, Stockholm, och Department of Neurosurgery, KS, Stockholm
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- Persson, Jonas K. E. (författare)
- Karolinska Institutet,Department of Clinical Neuroscience, KI, Stockholm, och Dept of Neurophysiology, KS, Stockholm
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- Åberg, Jonas (författare)
- Uppsala universitet,Tillämpad materialvetenskap
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- Blom, Hans (författare)
- KTH,Cellens fysik,Cell Physics, KTH, Stockholm
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- Engqvist, Håkan (författare)
- Uppsala universitet,Tillämpad materialvetenskap
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- Brismar, Hjalmar (författare)
- Karolinska Institutet,KTH,Cellens fysik,Cell Physics, KTH, Stockholm
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- Sjodahl, Johan (författare)
- GeoArctic Neuroscience AB, Stockholm
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- Josephson, Anna (författare)
- Karolinska Institutet,Dept of Neuroscience, KI, Stockholm
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- Frostell, Arvid (författare)
- Karolinska Institutet,Department of Clinical Neuroscience, KI, Stockholm
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- Thams, Sebastian (författare)
- Karolinska Institutet,Department of Clinical Neuroscience, KI, Stockholm
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- Brundin, Lou (författare)
- Karolinska Institutet,Department of Clinical Neuroscience, KI, Stockholm, och Dept of Neurology, KS, Stockholm
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- Svensson, Mikael (författare)
- Karolinska Institutet,Department of Clinical Neuroscience, KI, Stockholm, och Dept of Neurosurgery, KS, Stockholm
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- Mattsson, Per (författare)
- Karolinska Institutet,Department of Clinical Neuroscience, KI, Stockholm
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(creator_code:org_t)
- 2012
- 2012
- Engelska.
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Ingår i: Restorative Neurology and Neuroscience. - 0922-6028 .- 1878-3627. ; 30:2, s. 91-102
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Purpose: Repairing the spinal cord with peripheral nerve grafts (PNG) and adjuvant acidic fibroblast growth factor (FGF1) has previously resulted in partial functional recovery. To aid microsurgical placement of PNGs, a graft holder device was previously developed by our group. In hope for a translational development we now investigate a new biodegradable graft holder device containing PNGs with or without FGF1.Methods: Rats were subjected to a T11 spinal cord resection with subsequent repair using twelve white-to-grey matter oriented PNGs prepositioned in a biodegradable device with or without slow release of FGF1. Animals were evaluated with BBB-score, electrophysiology and immunohistochemistry including anterograde BDA tracing.Results: Motor evoked potentials (MEP) in the lower limb reappeared at 20 weeks after grafting. MEP responses were further improved in the group treated with adjuvant FGF1. Reappearance of MEPs was paralleled by NF-positive fibers and anterogradely traced corticospinal fibers distal to the injury. BBB-scores improved in repaired animals.Conclusions: The results continue to support that the combination of PNGs and FGF1 may be a regeneration strategy to reinnervate the caudal spinal cord. The new device induced robust MEPs augmented by FGF1, and may be considered for translational research.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Spinal cord injuries
- motor evoked potential
- rats
- peripheral nerves
- fibroblast growth factor 1
- tracing
- neurophysiology
- axonal regeneration
- TECHNOLOGY
- TEKNIKVETENSKAP
- Teknisk fysik med inriktning mot materialvetenskap
- Engineering Science with specialization in Materials Science
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Nordblom, Jonath ...
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Persson, Jonas K ...
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Åberg, Jonas
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Blom, Hans
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Engqvist, Håkan
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Brismar, Hjalmar
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visa fler...
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Sjodahl, Johan
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Josephson, Anna
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Frostell, Arvid
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Thams, Sebastian
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Brundin, Lou
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Svensson, Mikael
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Mattsson, Per
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Restorative Neur ...
- Av lärosätet
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Uppsala universitet
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Kungliga Tekniska Högskolan
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Karolinska Institutet