onr:"swepub:oai:DiVA.org:uu-17449"
Sökning: onr:"swepub:oai:DiVA.org:uu-17449" > The PSORS1 locus ge...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04269naa a2200613 4500 | |
| 001 | oai:DiVA.org:uu-17449 | |
| 003 | SwePub | |
| 008 | 080624s2008 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:116761544 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-174492 URI |
| 024 | 7 | a https://doi.org/10.1093/hmg/ddm3772 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1167615442 URI |
| 040 | a (SwePub)uud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Tiala, Inkeri4 aut |
| 245 | 1 0 | a The PSORS1 locus gene CCHCR1 affects keratinocyte proliferation in transgenic mice |
| 264 | c 2007-12-07 | |
| 264 | 1 | b Oxford University Press (OUP),c 2008 |
| 338 | a print2 rdacarrier | |
| 520 | a The CCHCR1 gene (Coiled-Coil alpha-Helical Rod protein 1) within the major psoriasis susceptibility locus PSORS1 is a plausible candidate gene for the risk effect. We have previously generated transgenic mice overexpressing either the psoriasis-associated risk allele CCHCR1*WWCC or the normal allele of CCHCR1. All transgenic CCHCR1 mice appeared phenotypically normal, but exhibited altered expression of genes relevant to the pathogenesis of psoriasis, including upregulation of hyperproliferation markers keratins 6, 16 and 17. Here, we challenged the skin of CCHCR1 transgenic mice with wounding or 12-O-tetradecanoyl-13-acetate (TPA), treatments able to induce epidermal hyperplasia and proliferation that both are hallmarks of psoriasis. These experiments revealed that CCHCR1 regulates keratinocyte proliferation. Early wound healing on days 1 and 4 was delayed, and TPA-induced epidermal hyperproliferation was less pronounced in mice with the CCHCR1*WWCC risk allele than in mice with the normal allele or in wild-type animals. Finally, we demonstrated that overexpression of CCHCR1 affects basal keratinocyte proliferation in mice; CCHCR1*WWCC mice had less proliferating keratinocytes than the non-risk allele mice. Similarly, keratinocytes isolated from risk allele mice proliferated more slowly in culture than wild-type cells when measured by BrdU labeling and ELISA. Our data show that CCHCR1 may function as a negative regulator of keratinocyte proliferation. Thus, aberrant function of CCHCR1 may lead to abnormal keratinocyte proliferation which is a key feature of psoriatic epidermis. | |
| 653 | a Animals | |
| 653 | a Cell Movement/drug effects | |
| 653 | a Cell Proliferation | |
| 653 | a Hyperplasia/chemically induced | |
| 653 | a Intracellular Signaling Peptides and Proteins/genetics/*metabolism | |
| 653 | a Keratinocytes/*cytology | |
| 653 | a Mice | |
| 653 | a Mice; Transgenic | |
| 653 | a Psoriasis/chemically induced/genetics/metabolism | |
| 653 | a Tetradecanoylphorbol Acetate | |
| 653 | a Wound Healing | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Wakkinen, Janica4 aut |
| 700 | 1 | a Suomela, Sari4 aut |
| 700 | 1 | a Puolakkainen, Pauli4 aut |
| 700 | 1 | a Tammi, Raija4 aut |
| 700 | 1 | a Forsberg, Sofiu Uppsala universitet,Institutionen för medicinska vetenskaper,Dermatologi och venereologi4 aut0 (Swepub:uu)sofor168 |
| 700 | 1 | a Rollman, Olau Uppsala universitet,Institutionen för medicinska vetenskaper,Dermatologi och venereologi4 aut0 (Swepub:uu)olarollm |
| 700 | 1 | a Kainu, Kati4 aut |
| 700 | 1 | a Rozell, Björnu Karolinska Institutet4 aut |
| 700 | 1 | a Kere, Juhau Karolinska Institutet4 aut |
| 700 | 1 | a Saarialho-Kere, Ulpuu Karolinska Institutet4 aut |
| 700 | 1 | a Elomaa, Outi4 aut |
| 710 | 2 | a Uppsala universitetb Institutionen för medicinska vetenskaper4 org |
| 773 | 0 | t Human Molecular Geneticsd : Oxford University Press (OUP)g 17:7, s. 1043-1051q 17:7<1043-1051x 0964-6906x 1460-2083 |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=18174193&dopt=Citation |
| 856 | 4 | u https://academic.oup.com/hmg/article-pdf/17/7/1043/17246093/ddm377.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-17449 |
| 856 | 4 8 | u https://doi.org/10.1093/hmg/ddm377 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:116761544 |
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