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Patterns of endogen...
Patterns of endogenous steroids in apathetic refugee children are compatible with long-term stress
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- Söndergaard, Hans Peter (författare)
- Karolinska Institutet,Department of Clinical Neuroscience, Karolinska Institutet, Sweden
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- Kushnir, Mark M (författare)
- Uppsala universitet,Analytisk kemi,Science for Life Laboratory, SciLifeLab
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- Aronsson, Bernice (författare)
- Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Sweden
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- Sandstedt, Per (författare)
- Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Sweden
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- Bergquist, Jonas (författare)
- Uppsala universitet,Analytisk kemi,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- 2012-04-23
- 2012
- Engelska.
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Ingår i: BMC Research Notes. - : Springer Science and Business Media LLC. - 1756-0500. ; 5:186
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://bmcresnotes....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUNDDuring the last few years, a number of children of asylum applicants in Sweden developed an apathetic or unconscious state. The syndrome was perceived as new, and various explanations were advanced such as; factitious disorder, intoxication, or stress. Considering a potential association between traumatic stress and regulation of steroids biosynthesis, this study explored whether changes in concentrations of endogenous steroids were associated with the above syndrome.METHODSEleven children were recruited in the study. Concentrations of steroids in blood samples were determined using high sensitivity liquid chromatography tandem mass spectrometry methods. Symptoms were assessed with a clinical rating scale developed for the study. Steroid concentrations were measured at the entry into study and after recovery; and concentrations were evaluated for the association with the symptoms in apathetic children.RESULTS Cortisol and cortisone concentrations at baseline were negatively associated with duration of the symptoms from entry into the study to clinical recovery. Concentrations of pregnanes (pregnenolone, 17-OH-pregnenolone, and dehydroepiandrosterone) and 17-OH-progesterone were increased in the symptomatic state and decreased after the recovery.CONCLUSIONS Pattern of low cortisol concentrations found in apathetic children is consistent with long-term stress. An increase of upstream steroid metabolites such as pregnanes and 17-OH-progesterone was found to be associated with the symptomatic state.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Nyckelord
- Apathetic refugee children
- Dissociative disorders
- Cortisol
- Steroids
- Neurosteroids
- Mass spectrometry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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