Sökning: onr:"swepub:oai:DiVA.org:uu-175985" > Data-driven unbiase...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03730naa a2200421 4500 | |
001 | oai:DiVA.org:uu-175985 | |
003 | SwePub | |
008 | 120614s2012 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:124817991 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1759852 URI |
024 | 7 | a https://doi.org/10.1073/pnas.12000191092 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1248179912 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Edlund, Karolinau Uppsala universitet,Molekylär och morfologisk patologi4 aut0 (Swepub:uu)kaedl086 |
245 | 1 0 | a Data-driven unbiased curation of the TP53 tumor suppressor gene mutation database and validation by ultradeep sequencing of human tumors |
264 | c 2012-05-24 | |
264 | 1 | b Proceedings of the National Academy of Sciences,c 2012 |
338 | a print2 rdacarrier | |
520 | a Cancer mutation databases are expected to play central roles in personalized medicine by providing targets for drug development and biomarkers to tailor treatments to each patient. The accuracy of reported mutations is a critical issue that is commonly overlooked, which leads to mutation databases that include a sizable number of spurious mutations, either sequencing errors or passenger mutations. Here we report an analysis of the latest version of the TP53 mutation database, including 34,453 mutations. By using several data-driven methods on multiple independent quality criteria, we obtained a quality score for each report contributing to the database. This score can now be used to filter for high-confidence mutations and reports within the database. Sequencing the entire TP53 gene from various types of cancer using next-generation sequencing with ultradeep coverage validated our approach for curation. In summary, 9.7% of all collected studies, mostly comprising numerous tumors with multiple infrequent TP53 mutations, should be excluded when analyzing TP53 mutations. Thus, by combining statistical and experimental analyses, we provide a curated mutation database for TP53 mutations and a framework for mutation database analysis. | |
700 | 1 | a Larsson, Olau Karolinska Institutet4 aut |
700 | 1 | a Ameur, Adamu Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi4 aut0 (Swepub:uu)adame789 |
700 | 1 | a Bunikis, Ignasu Uppsala universitet,Science for Life Laboratory, SciLifeLab,Genomik4 aut0 (Swepub:uu)ignbu776 |
700 | 1 | a Gyllensten, Ulfu Uppsala universitet,Science for Life Laboratory, SciLifeLab,Genomik4 aut0 (Swepub:uu)ulfgyll |
700 | 1 | a Leroy, Bernard4 aut |
700 | 1 | a Sundström, Magnusu Uppsala universitet,Molekylär och morfologisk patologi4 aut0 (Swepub:uu)magnsund |
700 | 1 | a Micke, Patricku Uppsala universitet,Molekylär och morfologisk patologi4 aut0 (Swepub:uu)patmi676 |
700 | 1 | a Botling, Johanu Uppsala universitet,Molekylär och morfologisk patologi4 aut0 (Swepub:uu)johanbot |
700 | 1 | a Soussi, Thierryu Karolinska Institutet4 aut |
710 | 2 | a Uppsala universitetb Molekylär och morfologisk patologi4 org |
773 | 0 | t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciencesg 109:24, s. 9551-9556q 109:24<9551-9556x 0027-8424x 1091-6490 |
856 | 4 | u https://www.pnas.org/content/pnas/109/24/9551.full.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-175985 |
856 | 4 8 | u https://doi.org/10.1073/pnas.1200019109 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:124817991 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.