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Gemtuzumab ozogamic...
Gemtuzumab ozogamicin as postconsolidation therapy does not prevent relapse in children with AML : results from NOPHO-AML 2004
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Hasle, Henrik (författare)
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Abrahamsson, Jonas (författare)
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- Forestier, Erik (författare)
- Umeå universitet,Institutionen för medicinsk biovetenskap
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Ha, Shau-Yin (författare)
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- Heldrup, Jesper (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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Jahnukainen, Kirsi (författare)
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Jonsson, Olafur Gisli (författare)
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Lausen, Birgitte (författare)
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- Palle, Josefine (författare)
- Uppsala universitet,Pediatrik
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Zeller, Bernward (författare)
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(creator_code:org_t)
- American Society of Hematology, 2012
- 2012
- Engelska.
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 120:5, s. 978-984
- Relaterad länk:
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https://ashpublicati...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- There are no data on the role of postconsolidation therapy with gemtuzumab ozogamicin (GO; Mylotarg) in children with acute myeloid leukemia (AML). The NOPHO-AML 2004 protocol studied postconsolidation randomization to GO or no further therapy. GO was administered at 5 mg/m(2) and repeated after 3 weeks. We randomized 120 patients; 59 to receive GO. Survival was analyzed on an intention-to-treat basis. The median follow-up for patients who were alive was 4.2 years. Children who received GO showed modest elevation of transaminase and bilirubin without signs of venoocclusive disease. Severe neutropenia followed 95% and febrile neutropenia 40% of the GO courses. Only a moderate decline in platelet count and a minor decrease in hemoglobin occurred. Relapse occurred in 24 and 25 of those randomized to GO or no further therapy. The median time to relapse was 16 months versus 10 months (nonsignificant). The 5-year event-free survival and overall survival was 55% versus 51% and 74% versus 80% in those randomized to receive GO or no further therapy, respectively. Results were similar in all subgroups. In conclusion, GO therapy postconsolidation as given in this trial was well tolerated, showed a nonsignificant delay in time to relapse, but did not change the rate of relapse or survival (clinicaltrials.gov identifier NCT00476541).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
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Blood
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Hasle, Henrik
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Abrahamsson, Jon ...
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Forestier, Erik
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Ha, Shau-Yin
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Heldrup, Jesper
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Jahnukainen, Kir ...
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visa fler...
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Jonsson, Olafur ...
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Lausen, Birgitte
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Palle, Josefine
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Zeller, Bernward
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
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Blood
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Uppsala universitet
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Umeå universitet
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Lunds universitet