Sökning: onr:"swepub:oai:DiVA.org:uu-181302" >
Genomic Variation i...
Genomic Variation in Seven Khoe-San Groups Reveals Adaptation and Complex African History
-
- Schlebusch, Carina M. (författare)
- Uppsala universitet,Evolutionsbiologi,Uppsala University
-
- Skoglund, Pontus (författare)
- Uppsala universitet,Evolutionsbiologi
-
- Sjödin, Per (författare)
- Uppsala universitet,Evolutionsbiologi
-
visa fler...
-
- Gattepaille, Lucie M. (författare)
- Uppsala universitet,Evolutionsbiologi
-
- Hernandez, Dena (författare)
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda
-
- Jay, Flora (författare)
- Department of Integrative Biology, University of California, BerkeleyDepartment of Integrative Biology, University of California, Berkeley
-
- Li, Sen (författare)
- Uppsala universitet,Evolutionsbiologi
-
- De Jongh, Michael (författare)
- Department of Anthropology and Archaeology, University of South Africa, Pretoria
-
- Singleton, Andrew (författare)
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda
-
- Blum, Michael G.B. (författare)
- Laboratoire TIMC-IMAG UMR 5525, Université Joseph Fourier, Centre National de la Recherche Scientifique, Grenoble
-
- Soodyall, Himla (författare)
- Human Genomic Diversity and Disease Research Unit, Division of Human Genetics, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg
-
- Jakobsson, Mattias (författare)
- Uppsala universitet,Evolutionsbiologi,Science for Life Laboratory, SciLifeLab
-
visa färre...
-
(creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2012
- 2012
- Engelska.
-
Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 338:6105, s. 374-379
- Relaterad länk:
-
https://uir.unisa.ac...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The history of click-speaking Khoe-San, and African populations in general, remains poorly understood. We genotyped ∼2.3 million SNPs in 220 southern Africans and found that the Khoe-San diverged from other populations ≥100,000 years ago, but structure within the Khoe-San dated back to about 35,000 years ago. Genetic variation in various sub-Saharan populations did not localize the origin of modern humans to a single geographic region within Africa; instead, it indicated a history of admixture and stratification. We found evidence of adaptation targeting muscle function and immune response, potential adaptive introgression of UV-light protection, and selection predating modern human diversification involving skeletal and neurological development. These new findings illustrate the importance of African genomic diversity in understanding human evolutionary history.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Science
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Schlebusch, Cari ...
-
Skoglund, Pontus
-
Sjödin, Per
-
Gattepaille, Luc ...
-
Hernandez, Dena
-
Jay, Flora
-
visa fler...
-
Li, Sen
-
De Jongh, Michae ...
-
Singleton, Andre ...
-
Blum, Michael G. ...
-
Soodyall, Himla
-
Jakobsson, Matti ...
-
visa färre...
- Artiklar i publikationen
-
Science
- Av lärosätet
-
Uppsala universitet