Sökning: onr:"swepub:oai:DiVA.org:uu-182582" >
Diagnosis according...
Diagnosis according to World Health Organization determines the long-term prognosis in patients with myeloproliferative neoplasms treated with anagrelide : Results of a prospective long-term follow-up
-
- Ejerblad, Elisabeth (författare)
- Uppsala universitet,Hematologi
-
Kvasnicka, Hans M (författare)
-
Thiele, Jürgen (författare)
-
visa fler...
-
Andreasson, Björn (författare)
-
- Björkholm, Magnus (författare)
- Karolinska Institutet
-
Löfvenberg, Eva (författare)
-
Markevärn, Berit (författare)
-
Merup, Mats (författare)
-
Nilssson, Lars (författare)
-
- Palmblad, Jan (författare)
- Karolinska Institutet
-
- Samuelsson, Jan (författare)
- Karolinska Institutet
-
- Birgegård, Gunnar (författare)
- Uppsala universitet,Hematologi
-
visa färre...
-
(creator_code:org_t)
- 2013
- 2013
- Engelska.
-
Ingår i: Hematology. - 1024-5332 .- 1607-8454. ; 18:1, s. 8-13
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- OBJECTIVES:During long term follow-up of a cohort of patients with essential thrombocythemia (ET) and polycythemia vera (PV) a higher than expected incidence of myelofibrosis (MF) was noted. In order to test if the explanation could be found in the diagnostic criteria a re-evaluation of diagnosis using the 2008 WHO diagnostic criteria for ET and MF was performed.METHODS: This prospective study of 60 patients with ET and PV was set up in 1998 to evaluate the long-term efficacy and tolerability of anagrelide treatment. Bone marrow trephine biopsies were requested from study start, after 2 and 7 years of follow-up. A blinded re-evaluation of the bone marrow trephines was performed. The 2008 WHO bone marrow criteria were used for diagnosis and fibrosis grading.RESULTS: Of 40 patients with an initial diagnosis of ET, 21 were confirmed as 'true ET' whereas 17 were reclassified as primary myelofibrosis (PMF) (12 PMF-0, 3 PMF-1, 2 PMF-2) and 2 as myeloproliferative neoplasms of uncertain origin. After 7 years of follow-up, 19 of 21 patients with 'true ET' were alive, none had transformed to MF, leukemia, or myelodysplastic syndrome. In contrast, 4/17 patients reclassified as PMF had died, two patients transformed to myelodysplastic syndrome and 7 patients progressed to overt MF.DISCUSSION:We conclude that a blinded re-evaluation of bone marrow trephines from study start and after 7 years of follow-up using 2008 World Health Organization criteria was able to differentiate between true ET and PMF with a marked difference in follow-up outcome.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Ejerblad, Elisab ...
-
Kvasnicka, Hans ...
-
Thiele, Jürgen
-
Andreasson, Björ ...
-
Björkholm, Magnu ...
-
Löfvenberg, Eva
-
visa fler...
-
Markevärn, Berit
-
Merup, Mats
-
Nilssson, Lars
-
Palmblad, Jan
-
Samuelsson, Jan
-
Birgegård, Gunna ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Hematologi
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Farmakologi och ...
- Artiklar i publikationen
-
Hematology
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet