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Validation of quest...
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Bergkvist, Charlotte
(författare)
Validation of questionnaire-based long-term dietary exposure to polychlorinated biphenyls using biomarkers
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
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2012-09-13
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Wiley,2012
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-185485
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-185485URI
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https://doi.org/10.1002/mnfr.201200196DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:125478268URI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Scope The health consequences of lifelong low-level exposure to polychlorinated biphenyls (PCBs) via food are largely unknown, mainly due to the lack of large population-based prospective studies addressing this issue. We validated long-term food frequency questionnaire (FFQ)-based dietary PCB exposure against concentrations of six PCB congeners in serum. Methods and results Dietary PCB exposure was estimated in the Swedish Mammography Cohort by constructing a recipe-based database of CB-153, an indicator for total PCBs in food. The Spearman rank correlation (adjusted for within-person variability) was assessed between concurrent (20042006), past (1997), and long-term (mean of 1997 and 20042006) FFQ-based dietary PCB exposure, respectively, and the following serum PCB congeners, CB-118, CB-138, CB-153, CB-156, CB-170, and CB-180, in women (5685 years of age, n = 201). The correlation between FFQ-based dietary PCB exposure and serum CB-153 was 0.41 (p < 0.001) for the concurrent (median 1.6 ng/kg body weight) and 0.34 (p < 0.05) for the past (median 2.6 ng/kg body weight) exposure assessment. Long-term validity of FFQ-based PCB estimates and the six serum PCB congeners ranged from 0.30 to 0.58 (p < 0.05). Conclusion FFQ-based PCB exposure estimates show acceptable validity in relation to PCB concentrations in serum, justifying their use in large-scale epidemiological studies.
Ämnesord och genrebeteckningar
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Dietary exposure
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Food frequency questionnaire
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Polychlorinated biphenyls
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Serum
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Validation study
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Åkesson, AgnetaKarolinska Institutet
(författare)
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Glynn, Anders
(författare)
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Michaëlsson, KarlUppsala universitet,Ortopedi(Swepub:uu)karlmich
(författare)
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Rantakokko, PanuUppsala universitet,Institutionen för kirurgiska vetenskaper
(författare)
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Kiviranta, HannuUppsala universitet,Institutionen för kirurgiska vetenskaper
(författare)
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Wolk, Alicja
(författare)
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Berglund, MarikaKarolinska Institutet
(författare)
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Karolinska InstitutetOrtopedi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Molecular Nutrition & Food Research: Wiley56:11, s. 1748-17541613-41251613-4133
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