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Factors Contributin...
Factors Contributing to the Lower Mortality With Ticagrelor Compared With Clopidogrel in Patients Undergoing Coronary Artery Bypass Surgery
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- Varenhorst, Christoph (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för medicinska vetenskaper,kardiologi
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- Alström, Ulrica (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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Scirica, Benjamin M. (författare)
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Hogue, Charles W. (författare)
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- Asenblad, Nils (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för medicinska vetenskaper
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Storey, Robert F. (författare)
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Steg, Gabriel (författare)
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Horrow, Jay (författare)
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Mahaffey, Kenneth W. (författare)
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Becker, Richard C. (författare)
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- James, Stefan (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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Cannon, Christopher P. (författare)
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Brandrup-Wognsen, Gunnar (författare)
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- Wallentin, Lars (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Held, Claes, 1956- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för medicinska vetenskaper
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- Engelska.
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Ingår i: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097 .- 1558-3597. ; 60:17, s. 1623-1630
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objectives This study investigated the differences in specific causes of post-coronary artery bypass graft surgery (CABG) deaths in the PLATO (Platelet Inhibition and Patient Outcomes) trial. Background In the PLATO trial, patients assigned to ticagrelor compared with clopidogrel and who underwent CABG had significantly lower total and cardiovascular mortality. Methods In the 1,261 patients with CABG performed within 7 days after stopping study drug, reviewers blinded to treatment assignment classified causes of death into subcategories of vascular and nonvascular, and specifically identified bleeding or infection events that either caused or subsequently contributed to death. Results Numerically more vascular deaths occurred in the clopidogrel versus the ticagrelor group related to myocardial infarction (14 vs. 10), heart failure (9 vs. 6), arrhythmia or sudden death (9 vs. 3), and bleeding, including hemorrhagic stroke (7 vs. 2). Clopidogrel was also associated with an excess of nonvascular deaths related to infection (8 vs. 2). Among factors directly causing or contributing to death, bleeding and infections were more common in the clopidogrel group compared with the ticagrelor group (infections: 16 vs. 6, p < 0.05, and bleeding: 27 vs. 9, p < 0.01, for clopidogrel and ticagrelor, respectively). Conclusions The mortality reduction with ticagrelor versus clopidogrel following CABG in the PLATO trial was associated with fewer deaths from cardiovascular, bleeding, and infection complications.
Nyckelord
- bypass
- clopidogrel
- myocardial infarction
- surgery
- ticagrelor
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Varenhorst, Chri ...
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Alström, Ulrica
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Scirica, Benjami ...
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Hogue, Charles W ...
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Asenblad, Nils
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Storey, Robert F ...
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visa fler...
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Steg, Gabriel
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Horrow, Jay
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Mahaffey, Kennet ...
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Becker, Richard ...
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James, Stefan
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Cannon, Christop ...
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Brandrup-Wognsen ...
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Wallentin, Lars
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Held, Claes, 195 ...
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Uppsala universitet