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Circulating 25-hydr...
Circulating 25-hydroxy-vitamin d and risk of cardiovascular disease : a meta-analysis of prospective studies
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Wang, Lu (författare)
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Song, Yiqing (författare)
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Manson, Joann E (författare)
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Pilz, Stefan (författare)
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März, Winfried (författare)
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- Michaëlsson, Karl, 1959- (författare)
- Uppsala universitet,Ortopedi
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Lundqvist, Annamari (författare)
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Jassal, Simerjot K (författare)
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Barrett-Connor, Elizabeth (författare)
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Zhang, Cuilin (författare)
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Eaton, Charles B (författare)
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May, Heidi T (författare)
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Anderson, Jeffrey L (författare)
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Sesso, Howard D (författare)
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(creator_code:org_t)
- 2012
- 2012
- Engelska.
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Ingår i: Circulation. Cardiovascular Quality and Outcomes. - 1941-7713 .- 1941-7705. ; 5:6, s. 819-829
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BackgroundVitamin D status has been linked to the risk of cardiovascular disease (CVD). However, the optimal 25-hydroxy-vitamin D (25[OH]-vitamin D) levels for potential cardiovascular health benefits remain unclear.Methods and ResultsWe searched MEDLINE and EMBASE from 1966 through February 2012 for prospective studies that assessed the association of 25(OH)-vitamin D concentrations with CVD risk. A total of 24 articles met our inclusion criteria, from which 19 independent studies with 6123 CVD cases in 65 994 participants were included for a meta-analysis. In a comparison of the lowest with the highest 25(OH)-vitamin D categories, the pooled relative risk was 1.52 (95% confidence interval, 1.30-1.77) for total CVD, 1.42 (95% confidence interval, 1.19-1.71) for CVD mortality, 1.38 (95% confidence interval, 1.21-1.57) for coronary heart disease, and 1.64 (95% confidence interval, 1.27-2.10) for stroke. These associations remained strong and significant when analyses were limited to studies that excluded participants with baseline CVD and were better controlled for season and confounding. We used a fractional polynomial spline regression analysis to assess the linearity of dose-response association between continuous 25(OH)-vitamin D and CVD risk. The CVD risk increased monotonically across decreasing 25(OH)-vitamin D below ≈60 nmol/L, with a relative risk of 1.03 (95% confidence interval, 1.00-1.06) per 25-nmol/L decrement in 25(OH)-vitamin D.ConclusionsThis meta-analysis demonstrated a generally linear, inverse association between circulating 25(OH)-vitamin D ranging from 20 to 60 nmol/L and risk of CVD. Further research is needed to clarify the association of 25(OH)-vitamin D higher than 60 nmol/L with CVD risk and assess causality of the observed associations.
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Wang, Lu
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Song, Yiqing
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Manson, Joann E
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Pilz, Stefan
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März, Winfried
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Michaëlsson, Kar ...
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visa fler...
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Lundqvist, Annam ...
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Jassal, Simerjot ...
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Barrett-Connor, ...
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Zhang, Cuilin
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Eaton, Charles B
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May, Heidi T
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Anderson, Jeffre ...
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Sesso, Howard D
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visa färre...
- Artiklar i publikationen
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Circulation. Car ...
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Uppsala universitet