Sökning: onr:"swepub:oai:DiVA.org:uu-193252" > Accounting for stra...
Fältnamn | Indikatorer | Metadata |
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000 | 02967naa a2200349 4500 | |
001 | oai:DiVA.org:uu-193252 | |
003 | SwePub | |
008 | 130129s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1932522 URI |
024 | 7 | a https://doi.org/10.3109/14756366.2013.8646512 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Ehrenberg, Angelicau Uppsala universitet,Institutionen för kemi - BMC4 aut0 (Swepub:uu)angeh349 |
245 | 1 0 | a Accounting for strain variations and resistance mutations in the characterization of hepatitis C NS3 protease inhibitors |
264 | c 2014-02-11 | |
264 | 1 | b Informa UK Limited,c 2014 |
338 | a print2 rdacarrier | |
520 | a Context: Natural strain variation and rapid resistance development makes development of broad spectrum hepatitis C virus (HCV) drugs very challenging and evaluation of inhibitor selectivity and resistance must account for differences in the catalytic properties of enzyme variants.Objective: To understand how to study selectivity and relationships between efficacy and genotype or resistant mutants for NS3 protease inhibitors.Materials and methods: The catalytic properties of NS3 protease from genotypes 1a, 1b and 3a, and their sensitivities to four structurally and mechanistically different NS3 protease inhibitors have been analysed under different experimental conditions.Results: The optimisation of buffer conditions for each protease variant enabled the comparison of their catalytic properties and sensitivities to the inhibitors. All inhibitors were most effective against genotype 1a protease, with VX-950 having the broadest selectivity.Discussion and conclusion: A new strategy for evaluation of inhibitors relevant for the discovery of broad spectrum HCV drugs was established. | |
650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
700 | 1 | a Schmuck, Benjaminu Uppsala universitet,Institutionen för kemi - BMC4 aut |
700 | 1 | a Anwar, Muhammad Ikramu Uppsala universitet,Institutionen för kemi - BMC4 aut |
700 | 1 | a Svahn Gustafsson, Sofiau Uppsala universitet,Institutionen för kemi - BMC4 aut0 (Swepub:uu)sofsv946 |
700 | 1 | a Stenberg, Gunu Uppsala universitet,Institutionen för kemi - BMC4 aut |
700 | 1 | a Danielson, Helenau Uppsala universitet,Institutionen för kemi - BMC4 aut0 (Swepub:uu)helenads |
710 | 2 | a Uppsala universitetb Institutionen för kemi - BMC4 org |
773 | 0 | t Journal of enzyme inhibition and medicinal chemistry (Print)d : Informa UK Limitedg 29:6, s. 868-876q 29:6<868-876x 1475-6366x 1475-6374 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-193252 |
856 | 4 8 | u https://doi.org/10.3109/14756366.2013.864651 |
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