onr:"swepub:oai:DiVA.org:uu-196611"
Sökning: onr:"swepub:oai:DiVA.org:uu-196611" > Structure of Alphac...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02553naa a2200337 4500 | |
| 001 | oai:DiVA.org:uu-196611 | |
| 003 | SwePub | |
| 008 | 130311s2013 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1966112 URI |
| 024 | 7 | a https://doi.org/10.1128/JVI.03163-122 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Jansson, Anna M.,d 1979-u Uppsala universitet,Struktur- och molekylärbiologi,T. Alwyn Jones4 aut0 (Swepub:uu)anjan838 |
| 245 | 1 0 | a Structure of Alphacoronavirus Transmissible Gastroenteritis Virus nsp1 Has Implications for Coronavirus nsp1 Function and Evolution |
| 264 | 1 | b American Society for Microbiology,c 2013 |
| 338 | a print2 rdacarrier | |
| 520 | a Coronavirus nsp1 has been shown to induce suppression of host gene expression and to interfere with the host immune re- sponse. However, the mechanism is currently unknown. The only available structural information on coronavirus nsp1 is the nuclear magnetic resonance (NMR) structure of the N-terminal domain of nsp1 from severe acute respiratory syndrome corona- virus (SARS-CoV) from the betacoronavirus genus. Here we present the first nsp1 structure from an alphacoronavirus, transmis- sible gastroenteritis virus (TGEV) nsp1. It displays a six-stranded -barrel fold with a long alpha helix on the rim of the barrel, a fold shared with SARS-CoV nsp113–128. Contrary to previous speculation, the TGEV nsp1 structure suggests that coronavirus nsp1s have a common origin, despite the lack of sequence homology. However, comparisons of surface electrostatics, shape, and amino acid conservation between the alpha- and betacoronaviruses lead us to speculate that the mechanism for nsp1-induced suppression of host gene expression might be different in these two genera. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Strukturbiologi0 (SwePub)106012 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Structural Biology0 (SwePub)106012 hsv//eng |
| 653 | a Coronavirus | |
| 653 | a Alphacoronavirus | |
| 653 | a nsp1 | |
| 653 | a Molecular Biology | |
| 653 | a Molekylärbiologi | |
| 710 | 2 | a Uppsala universitetb Struktur- och molekylärbiologi4 org |
| 773 | 0 | t Journal of Virologyd : American Society for Microbiologyg 87:5, s. 2949-2955q 87:5<2949-2955x 0022-538Xx 1098-5514 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-196611 |
| 856 | 4 8 | u https://doi.org/10.1128/JVI.03163-12 |
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Jansson, Anna M. ...
- Om ämnet
-
- NATURVETENSKAP
- NATURVETENSKAP
- och Biologi
- och Strukturbiologi
- Artiklar i publikationen
- Journal of Virol ...
- Av lärosätet
- Uppsala universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
