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Photocatalytic inac...
Photocatalytic inactivation of biofilms on bioactive dental adhesives
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- Cai, Yanling (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Strömme, Maria (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Melhus, Åsa (författare)
- Uppsala universitet,Klinisk bakteriologi
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- Engqvist, Håkan (författare)
- Uppsala universitet,Tillämpad materialvetenskap
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- Welch, Ken (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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(creator_code:org_t)
- 2013-07-11
- 2014
- Engelska.
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Ingår i: Journal of Biomedical Materials Research. Part B - Applied biomaterials. - : Wiley. - 1552-4973 .- 1552-4981. ; 102:1, s. 62-67
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Biofilms are the most prevalent mode of microbial life in nature and are 10-1000 times more resistant to antibiotics than planktonic bacteria. Persistent biofilm growth associated at the margin of a dental restoration often leads to secondary caries, which remains a challenge in restorative dentistry. In this work, we present the first in vitro evaluation of on-demand photocatalytic inactivation of biofilm on a novel dental adhesive containing TiO2 nanoparticles. Streptococcus mutans biofilm was cultured on this photocatalytic surface for 16 h before photocatalytic treatment with ultraviolet-A (UV-A) light. UV-A doses ranging from 3 to 43 J/cm(2) were applied to the surface and the resulting viability of biofilms was evaluated with a metabolic activity assay incorporating phenol red that provided a quantitative measure of the reduction in viability due to the photocatalytic treatments. We show that an UV-A irradiation dose of 8.4 J/cm(2) leads to one order of magnitude reduction in the number of biofilm bacteria on the surface of the dental adhesives while as much as 5-6 orders of magnitude reduction in the corresponding number can be achieved with a dose of 43 J/cm(2). This material maintains its functional properties as an adhesive in restorative dentistry while offering the possibility of a novel dental procedure in the treatment or prevention of bacterial infections via on-demand UV-A irradiation. Similar materials could be developed for the treatment of additional indications such as peri-implantits.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Nyckelord
- photocatalysis
- titanium dioxide
- biofilm inactivation
- Streptococcus mutans
- metabolic activity assay
- Teknisk fysik med inriktning mot nanoteknologi och funktionella material
- Engineering Science with specialization in Nanotechnology and Functional Materials
- Teknisk fysik med inriktning mot materialvetenskap
- Engineering Science with specialization in Materials Science
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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