Sökning: onr:"swepub:oai:DiVA.org:uu-197987" >
Plasma phosphatidyl...
-
Demirkan, Ayse
(författare)
Plasma phosphatidylcholine and sphingomyelin concentrations are associated with depression and anxiety symptoms in a Dutch family-based lipidomics study
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
-
Elsevier BV,2013
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-197987
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-197987URI
-
https://doi.org/10.1016/j.jpsychires.2012.11.001DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
The central nervous system has the second highest concentration of lipids after adipose tissue. Alterations in neural membrane phospho- and sphingolipid composition can influence crucial intra- and intercellular signalling and alter the membrane's properties. Recently, the polyunsaturated fatty acids (PUFA) hypothesis for depression suggests that phospho- and sphingolipid metabolism includes potential pathways for the disease. In 742 people from a Dutch family-based study, we assessed the relationships between 148 different plasma phospho- and sphingolipid species and depression/anxiety symptoms as measured by the Hospital Anxiety and Depression Scales (HADS-A and HADS-D) and the Centre for Epidemiological Studies Depression Scale (CES-D). We observed significant differences in plasma sphingomyelins (SPM), particularly the SPM 23:1/SPM 16:0 ratio, which was inversely correlated with depressive symptom scores. We observed a similar trend for plasma phosphatidylcholines (PC), particularly the molar proportion of PC O 36:4 and its ratio to ceramide CER 20:0. Absolute levels of PC O 36:4 were also associated with depression symptoms in an independent replication. To our knowledge this is the first study on depressive symptoms that focuses on specific phospho- and sphingolipid molecules in plasma rather than total PUFA concentrations. The findings of this lipidomic study suggests that plasma sphingomyelins and ether phospholipids should be further studied for their potential as biomarkers and for a better understanding of the underlying mechanisms of this systemic disease.
Ämnesord och genrebeteckningar
-
Lipidomics
-
Depression
-
Anxiety
-
Arachidonic acid
-
Phospholipid
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Isaacs, Aaron
(författare)
-
Ugocsai, Peter
(författare)
-
Liebisch, Gerhard
(författare)
-
Struchalin, Maksim
(författare)
-
Rudan, Igor
(författare)
-
Wilson, James F.
(författare)
-
Pramstaller, Peter P.
(författare)
-
Gyllensten, UlfUppsala universitet,Genomik,Rudbeck(Swepub:uu)ulfgyll
(författare)
-
Campbell, Harry
(författare)
-
Schmitz, Gerd
(författare)
-
Oostra, Ben A.
(författare)
-
van Duijn, Cornelia M.
(författare)
-
Uppsala universitetGenomik
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Journal of Psychiatric Research: Elsevier BV47:3, s. 357-3620022-39561879-1379
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Demirkan, Ayse
-
Isaacs, Aaron
-
Ugocsai, Peter
-
Liebisch, Gerhar ...
-
Struchalin, Maks ...
-
Rudan, Igor
-
visa fler...
-
Wilson, James F.
-
Pramstaller, Pet ...
-
Gyllensten, Ulf
-
Campbell, Harry
-
Schmitz, Gerd
-
Oostra, Ben A.
-
van Duijn, Corne ...
-
visa färre...
- Artiklar i publikationen
-
Journal of Psych ...
- Av lärosätet
-
Uppsala universitet