Sökning: onr:"swepub:oai:DiVA.org:uu-198620" > The genomic signatu...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04778naa a2200517 4500 | |
001 | oai:DiVA.org:uu-198620 | |
003 | SwePub | |
008 | 130422s2013 | |||||||||||000 ||eng| | |
009 | oai:slubar.slu.se:52119 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1986202 URI |
024 | 7 | a https://doi.org/10.1038/nature118372 DOI |
024 | 7 | a https://res.slu.se/id/publ/521192 URI |
040 | a (SwePub)uud (SwePub)slu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Axelsson, Eriku Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)eraxe021 |
245 | 1 0 | a The genomic signature of dog domestication reveals adaptation to a starch-rich diet |
264 | c 2013-01-23 | |
264 | 1 | b Springer Science and Business Media LLC,c 2013 |
338 | a print2 rdacarrier | |
520 | a The domestication of dogs. was an important episode in the development of human civilization. The precise timing and location of this event is debated(1-5) and little is known about the genetic changes that accompanied the transformation of ancient wolves into domestic dogs. Here we conduct whole-genome resequencimg of dogs and wolves to identify 3.8 million genetic variants used to identify 36 genomic regions that probably represent targets for selection during dog domestication. Nineteen of these regions contain genes important in brain function, eight of which belong to nervous system development pathways and potentially underlie behavioural changes central to dog domestication(6). Ten genes with key roles in starch digestion and fat metabolism also show signals of selection. We identify candidate mutations in key genes and provide functional support for an increased starch digestion in dogs relative to wolves. Our results indicate that novel adaptations allowing the early ancestors of modern dogs to thrive on a diet rich in starch, relative to the carnivorous diet of wolves, constituted a crucial step in the early domestication of dogs. | |
650 | 7 | a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Zoologi0 (SwePub)106082 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Zoology0 (SwePub)106082 hsv//eng |
650 | 7 | a LANTBRUKSVETENSKAPERx Veterinärmedicinx Annan veterinärmedicin0 (SwePub)403042 hsv//swe |
650 | 7 | a AGRICULTURAL SCIENCESx Veterinary Sciencex Other Veterinary Science0 (SwePub)403042 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Ekologi0 (SwePub)106112 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Ecology0 (SwePub)106112 hsv//eng |
700 | 1 | a Ratnakumar, Abhiramiu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)abhra806 |
700 | 1 | a Arendt, Maja Louiseu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)majar557 |
700 | 1 | a Maqbool, Khurramu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)khuma777 |
700 | 1 | a Webster, Matthew T.u Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)maweb226 |
700 | 1 | a Perloski, Michele4 aut |
700 | 1 | a Liberg, Olofu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för ekologi,Department of Ecology4 aut0 (Swepub:slu)50742 |
700 | 1 | a Arnemo, Jonu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för vilt, fisk och miljö,Department of Wildlife, Fish and Environmental Studies4 aut0 (Swepub:slu)49057 |
700 | 1 | a Hedhammar, Åkeu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences4 aut0 (Swepub:slu)49648 |
700 | 1 | a Lindblad-Toh, Kerstinu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)kerli865 |
710 | 2 | a Uppsala universitetb Institutionen för medicinsk biokemi och mikrobiologi4 org |
710 | 2 | a Sveriges lantbruksuniversitet |
773 | 0 | t Natured : Springer Science and Business Media LLCg 495:7441, s. 360-364q 495:7441<360-364x 0028-0836x 1476-4687 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-198620 |
856 | 4 8 | u https://doi.org/10.1038/nature11837 |
856 | 4 8 | u https://res.slu.se/id/publ/52119 |
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