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Sökning: onr:"swepub:oai:DiVA.org:uu-199609" > Poly(A)-specific ri...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02795naa a2200397 4500 | |
| 001 | oai:DiVA.org:uu-199609 | |
| 003 | SwePub | |
| 008 | 130508s2013 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:126475502 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1996092 URI |
| 024 | 7 | a https://doi.org/10.3109/10409238.2013.7711322 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1264755022 URI |
| 040 | a (SwePub)uud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a for2 swepub-publicationtype |
| 100 | 1 | a Virtanen, Andersu Uppsala universitet,Kemisk biologi4 aut0 (Swepub:uu)andevirt |
| 245 | 1 0 | a Poly(A)-specific ribonuclease (PARN) :b An allosterically regulated, processive and mRNA cap-interacting deadenylase |
| 264 | c 2013-03-15 | |
| 264 | 1 | b Informa UK Limited,c 2013 |
| 338 | a print2 rdacarrier | |
| 520 | a Deadenylation of eukaryotic mRNA is a mechanism critical for mRNA function by influencing mRNA turnover and efficiency of protein synthesis. Here, we review poly(A)-specific ribonuclease (PARN), which is one of the biochemically best characterized deadenylases. PARN is unique among the currently known eukaryotic poly(A) degrading nucleases, being the only deadenylase that has the capacity to directly interact during poly(A) hydrolysis with both the m 7 G-cap structure and the poly(A) tail of the mRNA. In short, PARN is a divalent metal-ion dependent poly(A)-specific, processive and cap-interacting 3'-5' exoribonuclease that efficiently degrades poly(A) tails of eukaryotic mRNAs. We discuss in detail the mechanisms of its substrate recognition, catalysis, allostery and processive mode of action. On the basis of biochemical and structural evidence, we present and discuss a working model for PARN action. Models of regulation of PARN activity by trans-acting factors are discussed as well as the physiological relevance of PARN. | |
| 653 | a Deadenylase | |
| 653 | a mRNA degradation | |
| 653 | a mRNA poly(A) tail degradation | |
| 653 | a mRNA turnover | |
| 653 | a ribonuclease | |
| 700 | 1 | a Henriksson, Niklasu Uppsala universitet,Kemisk biologi4 aut |
| 700 | 1 | a Nilsson, Peru Uppsala universitet,Kemisk biologi4 aut |
| 700 | 1 | a Nissbeck, Mikaelu Uppsala universitet,Kemisk biologi4 aut0 (Swepub:uu)mikni841 |
| 710 | 2 | a Uppsala universitetb Kemisk biologi4 org |
| 773 | 0 | t Critical reviews in biochemistry and molecular biologyd : Informa UK Limitedg 48:2, s. 192-209q 48:2<192-209x 1040-9238x 1549-7798 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-199609 |
| 856 | 4 8 | u https://doi.org/10.3109/10409238.2013.771132 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:126475502 |
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