Sökning: onr:"swepub:oai:DiVA.org:uu-200079" >
Low expression of m...
Low expression of microRNA-129-5p predicts poor clinical outcome in diffuse large B cell lymphoma (DLBCL)
-
- Hedström, Gustav (författare)
- Uppsala universitet,Enheten för onkologi
-
- Thunberg, Ulf (författare)
- Uppsala universitet,Enheten för onkologi
-
- Berglund, Mattias (författare)
- Uppsala universitet,Enheten för onkologi
-
visa fler...
-
- Simonsson, Martin (författare)
- Uppsala universitet,Enheten för onkologi
-
- Amini, Rose-Marie (författare)
- Uppsala universitet,Molekylär och morfologisk patologi
-
- Enblad, Gunilla (författare)
- Uppsala universitet,Enheten för onkologi
-
visa färre...
-
(creator_code:org_t)
- 2013-03-05
- 2013
- Engelska.
-
Ingår i: International Journal of Hematology. - : Springer Science and Business Media LLC. - 0925-5710 .- 1865-3774. ; 97:4, s. 465-471
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Diffuse large B cell lymphoma (DLBCL) is a heterogeneous group of B cell lymphomas. MicroRNA expression provides a new and interesting tool for understanding the biology and clinical course of DLBCL. The present study presents microRNA-129-5p expression data from DLBCL patients treated with CHOP or R-CHOP. Patients with low microRNA-129-5p expression had a median survival of 23 months and a significantly shorter overall survival (P = 0.0042) compared to patients with high microRNA-129-5p expression, who had a median survival of 58 months. We also found that patients treated with R-CHOP only and displaying low microRNA-129-5p expression had a significantly shorter overall survival compared to patients with high microRNA-129-5p expression; all such patients were still alive at the time of last follow-up (P = 0.043). No significant difference was found among microRNA-129-5p expression in tumor tissue, the tissue surrounding the tumor, and normal controls. To our knowledge, this is the first report to show that the expression of microRNA-129-5p can affect the clinical outcome of DLBCL patients and that microRNA-129-5p may be involved in the biology of DLBCL development, although larger studies are necessary to confirm this. Further investigations may also help to elucidate the biological role of microRNA-129-5p in DLBCL.
Nyckelord
- DLBCL
- microRNA-129-5p
- Prognosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas