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Arsenic exposure an...
Arsenic exposure and age- and sex-specific risk for skin lesions : A population-based case-referent study in Bangladesh
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Rahman, Mahfuzar (författare)
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- Vahter, Marie (författare)
- Karolinska Institutet
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Sohel, Nazmul (författare)
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Yunus, Muhammad (författare)
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Wahed, Mohammad Abdul (författare)
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Streatfield, Peter Kim (författare)
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- Ekström, Eva-Charlotte (författare)
- Uppsala universitet,Internationell mödra- och barnhälsovård (IMCH),Internationell kvinno- & mödrahälsovård/Lindmark
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- Persson, Lars-Åke (författare)
- Uppsala universitet,Internationell mödra- och barnhälsovård (IMCH),Internationell barnshälsovård och nutrition/Persson
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(creator_code:org_t)
- Environmental Health Perspectives, 2006
- 2006
- Engelska.
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Ingår i: Journal of Environmental Health Perspectives. - : Environmental Health Perspectives. - 0091-6765 .- 1552-9924. ; 114:12, s. 1847-1852
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
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- Background: The objective of this population-based case-referent study in Matlab, Bangladesh, was to assess the susceptibility to arsenic-induced skin lesions by age and sex, in a population drinking water from As-contaminated tube wells. Methods: Identification of As-related skin lesions was carried out in three steps: a) screening of the entire population > 4 years of age (n = 166,934) by trained field teams; b) diagnosis of suspected As-related cases by physicians; and c) confirmation by experts based on physicians' records and photographs, A total of 504 cases with skin lesions were confirmed. We randomly selected 2,201 referents from the Matlab health and demographic surveillance system; 1,955 were eligible, and 1,830 (94%) were available for participation in the study. Individual history of As exposure was based on information obtained during interviews and included all drinking-water sources used since 1970 and concentrations of As (assessed by atomic absorption spectrophotometry) in all the tube wells used. Results: Cases had been exposed to As more than referents (average exposure since 1970: male cases, 200 μg/L; female cases, 211 μg/L; male referents, 143 μg/L; female referents, 155 μg/L). We found a dose-response relationship for both sexes (p < 0.001) and increased risk with increasing socioeconomic status. Males had a higher risk of obtaining skin lesions than females (odds ratio 10.9 vs. 5.78) in the highest average exposure quintile (p = 0.005). Start of As exposure (cumulative exposure) before 1 year of age was not associated with higher risk of obtaining skin lesions compared to start of As exposure later in life. Conclusions: The results demonstrate that males are more susceptible than females to develop skin lesions when exposed to As in water from tube wells.
Nyckelord
- Arsenic skin lesions
- Bangladesh
- Case-referent study
- Dose response
- Drinking water
- Exposure
- Sex
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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