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Mid-regional pro-at...
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Eggers, Kai M.Uppsala universitet,Kardiologi
(författare)
Mid-regional pro-atrial natriuretic peptide levels in the elderly : Clinical and prognostic implications, and comparison to B-type natriuretic peptides
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
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Elsevier BV,2013
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-200690
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-200690URI
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https://doi.org/10.1016/j.cca.2013.01.020DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Background: Mid-regional pro-atrial natriuretic peptide (MR-proANP) is emerging as an indicator of cardiac abnormalities and adverse outcome in heart failure patients. However, there are only sparse data on its clinical value relative to the B-type natriuretic peptides in the general population. Methods: We measured levels of MR-proANP, B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) in 999 community-dwelling subjects aged 70 years who were participating in the PIVUS study. Results: The MR-proANP and the B-type natriuretic peptides exhibited similar associations to previous or prevalent cardiovascular disease, and echocardiographic data. In subgroups with confounding conditions (female sex, obesity, renal dysfunction), MR-proANP did not exhibit stronger associations to echocardiographic data than the B-type natriuretic peptides. MR-proANP predicted cardiovascular mortality during 8 years of follow-up (adjusted hazard ratio 2.8 [95% confidence interval 1.3-6.1]) but not all-cause mortality (adjusted hazard ratio 1.6[95% confidence interval 1.0-2.5]). Overall, NT-proBNP provided the strongest predictive value regarding both outcomes. Conclusions: MR-proANP levels in an elderly community population are to a similar extent as the B-type natriuretic peptides related to manifestations of cardiovascular disease and echocardiographic data. MR-proANP also predicts long-term cardiovascular mortality but without being prognostically superior compared to the B-type natriuretic peptides.
Ämnesord och genrebeteckningar
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MR-proANP
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B-type natriuretic peptides
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General population
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Risk prediction
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Venge, PerUppsala universitet,Biokemisk struktur och funktion(Swepub:uu)pervenge
(författare)
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Lind, LarsUppsala universitet,Kardiologi(Swepub:uu)larslind
(författare)
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Uppsala universitetKardiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Clinica Chimica Acta: Elsevier BV419, s. 62-660009-89811873-3492
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