Sökning: onr:"swepub:oai:DiVA.org:uu-202417" > SNP in TXNRD2 Assoc...
Fältnamn | Indikatorer | Metadata |
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000 | 03699naa a2200445 4500 | |
001 | oai:DiVA.org:uu-202417 | |
003 | SwePub | |
008 | 130624s2013 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2024172 URI |
024 | 7 | a https://doi.org/10.1016/j.ijrobp.2013.02.0252 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Edvardsen, Hege4 aut |
245 | 1 0 | a SNP in TXNRD2 Associated With Radiation-Induced Fibrosis :b A Study of Genetic Variation in Reactive Oxygen Species Metabolism and Signaling. |
264 | 1 | b Elsevier BV,c 2013 |
338 | a print2 rdacarrier | |
520 | a PURPOSE: The aim of the study was to identify noninvasive markers of treatment-induced side effects. Reactive oxygen species (ROS) are generated after irradiation, and genetic variation in genes related to ROS metabolism might influence the level of radiation-induced adverse effects (AEs).METHODS AND MATERIALS: 92 breast cancer (BC) survivors previously treated with hypofractionated radiation therapy were assessed for the AEs subcutaneous atrophy and fibrosis, costal fractures, lung fibrosis, pleural thickening, and telangiectasias (median follow-up time 17.1 years). Single-nucleotide polymorphisms (SNPs) in 203 genes were analyzed for association to AE grade. SNPs associated with subcutaneous fibrosis were validated in an independent BC survivor material (n=283). The influence of the studied genetic variation on messenger ribonucleic acid (mRNA) expression level of 18 genes previously associated with fibrosis was assessed in fibroblast cell lines from BC patients.RESULTS: Subcutaneous fibrosis and atrophy had the highest correlation (r=0.76) of all assessed AEs. The nonsynonymous SNP rs1139793 in TXNRD2 was associated with grade of subcutaneous fibrosis, the reference T-allele being more prevalent in the group experiencing severe levels of fibrosis. This was confirmed in another sample cohort of 283 BC survivors, and rs1139793 was found significantly associated with mRNA expression level of TXNRD2 in blood. Genetic variation in 24 ROS-related genes, including EGFR, CENPE, APEX1, and GSTP1, was associated with mRNA expression of 14 genes previously linked to fibrosis (P≤.005).CONCLUSION: Development of subcutaneous fibrosis can be associated with genetic variation in the mitochondrial enzyme TXNRD2, critically involved in removal of ROS, and maintenance of the intracellular redox balance. | |
653 | a Molekylär medicin | |
653 | a Molecular Medicine | |
700 | 1 | a Landmark-Høyvik, Hege4 aut |
700 | 1 | a Reinertsen, Kristin V4 aut |
700 | 1 | a Zhao, Xi4 aut |
700 | 1 | a Grenaker-Alnæs, Grethe Irene4 aut |
700 | 1 | a Nebdal, Daniel4 aut |
700 | 1 | a Syvänen, Ann-Christine,d 1950-u Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär medicin,Molmed4 aut0 (Swepub:uu)anncsyva |
700 | 1 | a Rødningen, Olaug4 aut |
700 | 1 | a Alsner, Jan4 aut |
700 | 1 | a Overgaard, Jens4 aut |
700 | 1 | a Borresen-Dale, Anne-Lise4 aut |
700 | 1 | a Fosså, Sophie D4 aut |
700 | 1 | a Kristensen, Vessela N4 aut |
710 | 2 | a Uppsala universitetb Science for Life Laboratory, SciLifeLab4 org |
773 | 0 | t International journal of radiation oncology, biology, physicsd : Elsevier BVg 86:4, s. 791-9q 86:4<791-9x 1879-355Xx 0360-3016 |
856 | 4 | u https://doi.org/10.1016/j.ijrobp.2013.02.025y Fulltext |
856 | 4 | u https://doi.org/10.1016/j.ijrobp.2013.02.025 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-202417 |
856 | 4 8 | u https://doi.org/10.1016/j.ijrobp.2013.02.025 |
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