Omega-3 from fish oil augments GVHD through the enhancement of chemotherapy conditioning regimen and selective FoxP3 depletion

Omega-3 is known to enhance the effects of several chemotherapeutic agents and to exert several immunoregulatory actions In the present study, we evaluated the effects of a 21-day feeding regimen with omega-3-rich fish oil (FO) and its corresponding control, omega-6 rich corn oil (CO), on the BU-CY conditioning and the development of GVHD after BMT in mice. Before conditioning, FO, but not CO, feeding caused a significant attenuation in the number and functionality of splenic FoxP3+ T regulatory cells (Treg). FO feeding also enhanced the effects of the conditioning through severe depletion of Treg cells in the spleen and CD11b+ myeloid cells in both the BM and spleen. Consequently, FO-fed animals conditioned with BU-CY showed exacerbated GVHD following transplantation with allogeneic BM and splenic cells. In contrast, identical transplantation in CO-fed mice resulted in poor engraftment and body weight loss. Moreover, in standard-fed recipients, BMT with cells from FO-fed donors resulted in moderate GVHD and improved the survival time, whereas BMT with cells from CO-fed donors shortened the survival time and caused anemia. We conclude that food supplements should be considered in patients undergoing BMT and/or chemotherapy treatment.

Sadeghi, B.Karolinska Institutet (författare)
Hassan, Z. (författare)
Abedi-Valugerdi, M.Karolinska Institutet (författare)
Lindskog, MagnusKarolinska Institutet,Uppsala universitet,Enheten för onkologi(Swepub:uu)magli409 (författare)
Hassan, M.Karolinska Institutet (författare)
Karolinska InstitutetEnheten för onkologi (creator_code:org_t)

Ingår i:Bone Marrow Transplantation: Springer Science and Business Media LLC48:6, s. 843-8480268-33691476-5365

Av författaren/redakt...: Al Hashmi, S.; Sadeghi, B.; Hassan, Z.; Abedi-Valugerdi, ...; Lindskog, Magnus; Hassan, M.

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