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Toward Prediction o...
Toward Prediction of Efficacy of Chemotherapy : A Proof of Concept Study in Lung Cancer Patients Using [11C]docetaxel and Positron Emission Tomography
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van der Veldt, Astrid A. M. (författare)
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- Lubberink, Mark (författare)
- Uppsala universitet,Enheten för nuklearmedicin och PET
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Mathijssen, Ron H. J. (författare)
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Loos, Walter J. (författare)
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Herder, Gerarda J. M. (författare)
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Greuter, Henri N. (författare)
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Comans, Emile F. I. (författare)
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Rutten, Hugo B. (författare)
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- Eriksson, Jonas (författare)
- VU University Medical Center Amsterdam
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Windhorst, Albert D. (författare)
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Hendrikse, N. Harry (författare)
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Postmus, Pieter E. (författare)
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Smit, Egbert F. (författare)
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Lammertsma, Adriaan A. (författare)
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(creator_code:org_t)
- 2013
- 2013
- Engelska.
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Ingår i: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 19:15, s. 4163-4173
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Purpose:Pharmacokinetics of docetaxel can be measured in vivo using positron emission tomography (PET) and a microdose of radiolabeled docetaxel ([11C]docetaxel). The objective of this study was to investigate whether a [11C]docetaxel PET microdosing study could predict tumor uptake of therapeutic doses of docetaxel.Experimental Design:Docetaxel-naïve lung cancer patients underwent 2 [11C]docetaxel PET scans; one after bolus injection of [11C]docetaxel and another during combined infusion of [11C]docetaxel and a therapeutic dose of docetaxel (75 mg·m−2). Compartmental and spectral analyses were used to quantify [11C]docetaxel tumor kinetics. [11C]docetaxel PET measurements were used to estimate the area under the curve (AUC) of docetaxel in tumors. Tumor response was evaluated using computed tomography scans.Results:Net rates of influx (Ki) of [11C]docetaxel in tumors were comparable during microdosing and therapeutic scans. [11C]docetaxel AUCTumor during the therapeutic scan could be predicted reliably using an impulse response function derived from the microdosing scan together with the plasma curve of [11C]docetaxel during the therapeutic scan. At 90 minutes, the accumulated amount of docetaxel in tumors was less than 1% of the total infused dose of docetaxel. [11C]docetaxel Ki derived from the microdosing scan correlated with AUCTumor of docetaxel (Spearman ρ = 0.715; P = 0.004) during the therapeutic scan and with tumor response to docetaxel therapy (Spearman ρ = −0.800; P = 0.010).Conclusions:Microdosing data of [11C]docetaxel PET can be used to predict tumor uptake of docetaxel during chemotherapy. The present study provides a framework for investigating the PET microdosing concept for radiolabeled anticancer drugs in patients.
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van der Veldt, A ...
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Lubberink, Mark
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Mathijssen, Ron ...
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Loos, Walter J.
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Herder, Gerarda ...
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Greuter, Henri N ...
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visa fler...
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Comans, Emile F. ...
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Rutten, Hugo B.
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Eriksson, Jonas
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Windhorst, Alber ...
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Hendrikse, N. Ha ...
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Postmus, Pieter ...
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Smit, Egbert F.
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Lammertsma, Adri ...
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Uppsala universitet