Sökning: onr:"swepub:oai:DiVA.org:uu-206563" > Toward Prediction o...
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000 | 03468naa a2200409 4500 | |
001 | oai:DiVA.org:uu-206563 | |
003 | SwePub | |
008 | 130902s2013 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2065632 URI |
024 | 7 | a https://doi.org/10.1158/1078-0432.CCR-12-37792 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a van der Veldt, Astrid A. M.4 aut |
245 | 1 0 | a Toward Prediction of Efficacy of Chemotherapy :b A Proof of Concept Study in Lung Cancer Patients Using [11C]docetaxel and Positron Emission Tomography |
264 | 1 | c 2013 |
338 | a print2 rdacarrier | |
520 | a Purpose:Pharmacokinetics of docetaxel can be measured in vivo using positron emission tomography (PET) and a microdose of radiolabeled docetaxel ([11C]docetaxel). The objective of this study was to investigate whether a [11C]docetaxel PET microdosing study could predict tumor uptake of therapeutic doses of docetaxel.Experimental Design:Docetaxel-naïve lung cancer patients underwent 2 [11C]docetaxel PET scans; one after bolus injection of [11C]docetaxel and another during combined infusion of [11C]docetaxel and a therapeutic dose of docetaxel (75 mg·m−2). Compartmental and spectral analyses were used to quantify [11C]docetaxel tumor kinetics. [11C]docetaxel PET measurements were used to estimate the area under the curve (AUC) of docetaxel in tumors. Tumor response was evaluated using computed tomography scans.Results:Net rates of influx (Ki) of [11C]docetaxel in tumors were comparable during microdosing and therapeutic scans. [11C]docetaxel AUCTumor during the therapeutic scan could be predicted reliably using an impulse response function derived from the microdosing scan together with the plasma curve of [11C]docetaxel during the therapeutic scan. At 90 minutes, the accumulated amount of docetaxel in tumors was less than 1% of the total infused dose of docetaxel. [11C]docetaxel Ki derived from the microdosing scan correlated with AUCTumor of docetaxel (Spearman ρ = 0.715; P = 0.004) during the therapeutic scan and with tumor response to docetaxel therapy (Spearman ρ = −0.800; P = 0.010).Conclusions:Microdosing data of [11C]docetaxel PET can be used to predict tumor uptake of docetaxel during chemotherapy. The present study provides a framework for investigating the PET microdosing concept for radiolabeled anticancer drugs in patients. | |
700 | 1 | a Lubberink, Marku Uppsala universitet,Enheten för nuklearmedicin och PET4 aut0 (Swepub:uu)marklubb |
700 | 1 | a Mathijssen, Ron H. J.4 aut |
700 | 1 | a Loos, Walter J.4 aut |
700 | 1 | a Herder, Gerarda J. M.4 aut |
700 | 1 | a Greuter, Henri N.4 aut |
700 | 1 | a Comans, Emile F. I.4 aut |
700 | 1 | a Rutten, Hugo B.4 aut |
700 | 1 | a Eriksson, Jonasu VU University Medical Center Amsterdam4 aut0 (Swepub:uu)joeri542 |
700 | 1 | a Windhorst, Albert D.4 aut |
700 | 1 | a Hendrikse, N. Harry4 aut |
700 | 1 | a Postmus, Pieter E.4 aut |
700 | 1 | a Smit, Egbert F.4 aut |
700 | 1 | a Lammertsma, Adriaan A.4 aut |
710 | 2 | a Uppsala universitetb Enheten för nuklearmedicin och PET4 org |
773 | 0 | t Clinical Cancer Researchg 19:15, s. 4163-4173q 19:15<4163-4173x 1078-0432x 1557-3265 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-206563 |
856 | 4 8 | u https://doi.org/10.1158/1078-0432.CCR-12-3779 |
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