Sökning: onr:"swepub:oai:DiVA.org:uu-206759" > The Role of Adiposi...
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000 | 10933naa a2201933 4500 | |
001 | oai:DiVA.org:uu-206759 | |
003 | SwePub | |
008 | 130904s2013 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:5ad70ca3-e840-4447-88b1-f702fdef0240 | |
009 | oai:prod.swepub.kib.ki.se:127098376 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2067592 URI |
024 | 7 | a https://doi.org/10.1371/journal.pmed.10014742 DOI |
024 | 7 | a https://lup.lub.lu.se/record/39752102 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1270983762 URI |
040 | a (SwePub)uud (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Fall, Toveu Uppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)tovfa878 |
245 | 1 0 | a The Role of Adiposity in Cardiometabolic Traits :b A Mendelian Randomization Analysis |
264 | c 2013-06-25 | |
264 | 1 | b Public Library of Science (PLoS),c 2013 |
338 | a electronic2 rdacarrier | |
500 | a De fyra sista författarna delar sistaförfattarskapet. | |
520 | a Background: The association between adiposity and cardiometabolic traits is well known from epidemiological studies. Whilst the causal relationship is clear for some of these traits, for others it is not. We aimed to determine whether adiposity is causally related to various cardiometabolic traits using the Mendelian randomization approach. Methods and Findings: We used the adiposity-associated variant rs9939609 at the FTO locus as an instrumental variable (IV) for body mass index (BMI) in a Mendelian randomization design. Thirty-six population-based studies of individuals of European descent contributed to the analyses. Age-and sex-adjusted regression models were fitted to test for association between (i) rs9939609 and BMI (n = 198,502), (ii) rs9939609 and 24 traits, and (iii) BMI and 24 traits. The causal effect of BMI on the outcome measures was quantified by IV estimators. The estimators were compared to the BMI-trait associations derived from the same individuals. In the IV analysis, we demonstrated novel evidence for a causal relationship between adiposity and incident heart failure (hazard ratio, 1.19 per BMI-unit increase; 95% CI, 1.03-1.39) and replicated earlier reports of a causal association with type 2 diabetes, metabolic syndrome, dyslipidemia, and hypertension (odds ratio for IV estimator, 1.1-1.4; all p<0.05). For quantitative traits, our results provide novel evidence for a causal effect of adiposity on the liver enzymes alanine aminotransferase and gamma-glutamyl transferase and confirm previous reports of a causal effect of adiposity on systolic and diastolic blood pressure, fasting insulin, 2-h post-load glucose from the oral glucose tolerance test, C-reactive protein, triglycerides, and high-density lipoprotein cholesterol levels (all p<0.05). The estimated causal effects were in agreement with traditional observational measures in all instances except for type 2 diabetes, where the causal estimate was larger than the observational estimate (p = 0.001). Conclusions: We provide novel evidence for a causal relationship between adiposity and heart failure as well as between adiposity and increased liver enzymes. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Hägg, Sarau Karolinska Institutet,Uppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)sarha464 |
700 | 1 | a Maegi, Reedik4 aut |
700 | 1 | a Ploner, Alexanderu Karolinska Institutet4 aut |
700 | 1 | a Fischer, Krista4 aut |
700 | 1 | a Horikoshi, Momoko4 aut |
700 | 1 | a Sarin, Antti-Pekka4 aut |
700 | 1 | a Thorleifsson, Gudmar4 aut |
700 | 1 | a Ladenvall, Claesu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)med-cll |
700 | 1 | a Kals, Mart4 aut |
700 | 1 | a Kuningas, Maris4 aut |
700 | 1 | a Draisma, Harmen H. M.4 aut |
700 | 1 | a Ried, Janina S.4 aut |
700 | 1 | a van Zuydam, Natalie R.4 aut |
700 | 1 | a Huikari, Ville4 aut |
700 | 1 | a Mangino, Massimo4 aut |
700 | 1 | a Sonestedt, Emilyu Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-eso |
700 | 1 | a Benyamin, Beben4 aut |
700 | 1 | a Nelson, Christopher P.4 aut |
700 | 1 | a Rivera, Natalia V.4 aut |
700 | 1 | a Kristiansson, Kati4 aut |
700 | 1 | a Shen, Huei-yi4 aut |
700 | 1 | a Havulinna, Aki S.4 aut |
700 | 1 | a Dehghan, Abbas4 aut |
700 | 1 | a Donnelly, Louise A.4 aut |
700 | 1 | a Kaakinen, Marika4 aut |
700 | 1 | a Nuotio, Marja-Liisa4 aut |
700 | 1 | a Robertson, Neil4 aut |
700 | 1 | a de Bruijn, Renee F. A. G.4 aut |
700 | 1 | a Ikram, M. Arfan4 aut |
700 | 1 | a Amin, Najaf4 aut |
700 | 1 | a Balmforth, Anthony J.4 aut |
700 | 1 | a Braund, Peter S.4 aut |
700 | 1 | a Doney, Alexander S. F.4 aut |
700 | 1 | a Doering, Angela4 aut |
700 | 1 | a Elliott, Paul4 aut |
700 | 1 | a Esko, Tonu4 aut |
700 | 1 | a Franco, Oscar H.4 aut |
700 | 1 | a Gretarsdottir, Solveig4 aut |
700 | 1 | a Hartikainen, Anna-Liisa4 aut |
700 | 1 | a Heikkila, Kauko4 aut |
700 | 1 | a Herzig, Karl-Heinz4 aut |
700 | 1 | a Holm, Hilma4 aut |
700 | 1 | a Hottenga, Jouke Jan4 aut |
700 | 1 | a Hypponen, Elina4 aut |
700 | 1 | a Illig, Thomas4 aut |
700 | 1 | a Isaacs, Aaron4 aut |
700 | 1 | a Isomaa, Bo4 aut |
700 | 1 | a Karssen, Lennart C.4 aut |
700 | 1 | a Kettunen, Johannes4 aut |
700 | 1 | a Koenig, Wolfgang4 aut |
700 | 1 | a Kuulasmaa, Kari4 aut |
700 | 1 | a Laatikainen, Tiina4 aut |
700 | 1 | a Laitinen, Jaana4 aut |
700 | 1 | a Lindgren, Cecilia4 aut |
700 | 1 | a Lyssenko, Valeriyau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-vly |
700 | 1 | a Laara, Esa4 aut |
700 | 1 | a Rayner, Nigel W.4 aut |
700 | 1 | a Mannisto, Satu4 aut |
700 | 1 | a Pouta, Anneli4 aut |
700 | 1 | a Rathmann, Wolfgang4 aut |
700 | 1 | a Rivadeneira, Fernando4 aut |
700 | 1 | a Ruokonen, Aimo4 aut |
700 | 1 | a Savolainen, Markku J.4 aut |
700 | 1 | a Sijbrands, Eric J. G.4 aut |
700 | 1 | a Small, Kerrin S.4 aut |
700 | 1 | a Smit, Jan H.4 aut |
700 | 1 | a Steinthorsdottir, Valgerdur4 aut |
700 | 1 | a Syvänen, Ann-Christineu Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)anncsyva |
700 | 1 | a Taanila, Anja4 aut |
700 | 1 | a Tobin, Martin D.4 aut |
700 | 1 | a Uitterlinden, Andre G.4 aut |
700 | 1 | a Willems, Sara M.4 aut |
700 | 1 | a Willemsen, Gonneke4 aut |
700 | 1 | a Witteman, Jacqueline4 aut |
700 | 1 | a Perola, Markus4 aut |
700 | 1 | a Evans, Alun4 aut |
700 | 1 | a Ferrieres, Jean4 aut |
700 | 1 | a Virtamo, Jarmo4 aut |
700 | 1 | a Kee, Frank4 aut |
700 | 1 | a Tregouet, David-Alexandre4 aut |
700 | 1 | a Arveiler, Dominique4 aut |
700 | 1 | a Amouyel, Philippe4 aut |
700 | 1 | a Ferrario, Marco M.4 aut |
700 | 1 | a Brambilla, Paolo4 aut |
700 | 1 | a Hall, Alistair S.4 aut |
700 | 1 | a Heath, AndrewC.4 aut |
700 | 1 | a Madden, Pamela A. F.4 aut |
700 | 1 | a Martin, Nicholas G.4 aut |
700 | 1 | a Montgomery, Grant W.4 aut |
700 | 1 | a Whitfield, John B.4 aut |
700 | 1 | a Jula, Antti4 aut |
700 | 1 | a Knekt, Paul4 aut |
700 | 1 | a Oostra, Ben4 aut |
700 | 1 | a van Duijn, Cornelia M.4 aut |
700 | 1 | a Penninx, Brenda W. J. H.4 aut |
700 | 1 | a Smith, George Davey4 aut |
700 | 1 | a Kaprio, Jaakko4 aut |
700 | 1 | a Samani, Nilesh J.4 aut |
700 | 1 | a Gieger, Christian4 aut |
700 | 1 | a Peters, Annette4 aut |
700 | 1 | a Wichmann, H. -Erich4 aut |
700 | 1 | a Boomsma, Dorret I.4 aut |
700 | 1 | a de Geus, Eco J. C.4 aut |
700 | 1 | a Tuomi, TiinaMaija4 aut |
700 | 1 | a Power, Chris4 aut |
700 | 1 | a Hammond, Christopher J.4 aut |
700 | 1 | a Spector, Tim D.4 aut |
700 | 1 | a Lind, Larsu Karolinska Institutet,Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind |
700 | 1 | a Orho-Melander, Marjuu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor |
700 | 1 | a Palmer, Colin Neil Alexander4 aut |
700 | 1 | a Morris, Andrew D.4 aut |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
700 | 1 | a Jarvelin, Marjo-Riitta4 aut |
700 | 1 | a Salomaa, Veikko4 aut |
700 | 1 | a Vartiainen, Erkki4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Ripatti, Samuli4 aut |
700 | 1 | a Metspalu, Andres4 aut |
700 | 1 | a Thorsteinsdottir, Unnur4 aut |
700 | 1 | a Stefansson, Kari4 aut |
700 | 1 | a Pedersen, Nancy L.4 aut |
700 | 1 | a McCarthy, Mark I.4 aut |
700 | 1 | a Ingelsson, Eriku Uppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ering425 |
700 | 1 | a Prokopenko, Inga4 aut |
710 | 2 | a Uppsala universitetb Institutionen för medicinska vetenskaper4 org |
773 | 0 | t PLoS Medicined : Public Library of Science (PLoS)g 10:6, s. e1001474-q 10:6<e1001474-x 1549-1277x 1549-1676 |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:645396/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1001474&type=printable |
856 | 4 | u https://portal.research.lu.se/files/2400793/4391330.pdfx primaryx freey FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1371/journal.pmed.1001474x freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-206759 |
856 | 4 8 | u https://doi.org/10.1371/journal.pmed.1001474 |
856 | 4 8 | u https://lup.lub.lu.se/record/3975210 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:127098376 |
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