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Evaluation of the q...
Evaluation of the quality of blood components obtained after automated separation of whole blood by a new multiunit processor
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- Lagerberg, Johan W. (författare)
- Uppsala universitet,Klinisk immunologi
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- Salado-Jimena, Jose A. (författare)
- Uppsala universitet,Klinisk immunologi
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- Lööf, Helena (författare)
- Uppsala universitet,Klinisk immunologi
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- Bontekoe, Ido J. (författare)
- Uppsala universitet,Klinisk immunologi
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- Nielsen, Connie (författare)
- Uppsala universitet,Klinisk immunologi
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- Verheggen, Caroline (författare)
- Uppsala universitet,Klinisk immunologi
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- van Waeg, Geert (författare)
- Uppsala universitet,Klinisk immunologi
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- van der Meer, Pieter F. (författare)
- Uppsala universitet,Klinisk immunologi
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- de Korte, Dirk (författare)
- Uppsala universitet,Klinisk immunologi
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- Hansen, Morten B. (författare)
- Uppsala universitet,Klinisk immunologi
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- Knutson, Folke (författare)
- Uppsala universitet,Klinisk immunologi
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(creator_code:org_t)
- 2012-12-11
- 2013
- Engelska.
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Ingår i: Transfusion. - : Wiley. - 0041-1132 .- 1537-2995. ; 53:8, s. 1798-1807
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: The Reveos system (Terumo BCT) is a fully automated device able to process four whole blood (WB) units simultaneously into a plasma unit, a red blood cell (RBC) unit, and an interim platelet (PLT) unit (IPU). Multiple IPUs can be pooled to form a transfusable PLT product. The aim of our study was to evaluate the quality of components made with the Reveos system from either fresh (2-8hr) or overnight-held WB. STUDY DESIGN AND METHODS: A prototype of the Reveos system was used to process WB. RBCs were resuspended in SAGM, leukoreduced, and assayed for in vitro quality variables during a 42-day storage period at 2 to 6 degrees C. Twenty-four-hour in vivo recovery was determined on Day42. Plasma was assayed for cellular contamination and activation variables. IPUs were pooled with SSP+ additive solution for in vitro quality assessments during a 7-day storage period at room temperature. RESULTS: Reveos-produced RBCs and plasma units met the predefined requirements. RBC recovery was superior to control units. On Day42, hemolysis was below 0.8% and in vivo recovery was above 75% for all RBCs. Cellular contamination was lower for Reveos-produced plasma. PLT yield was higher with overnight-stored WB. PLT quality was well maintained during storage with no significant differences between the two groups. Conclusion: Blood components prepared with the Reveos from fresh or overnight-held WB meet quality criteria without any relevant difference between the two groups. The Reveos system has the potential to increase efficacy and standardization of blood component preparation.
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Lagerberg, Johan ...
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Salado-Jimena, J ...
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Lööf, Helena
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Bontekoe, Ido J.
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Nielsen, Connie
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Verheggen, Carol ...
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visa fler...
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van Waeg, Geert
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van der Meer, Pi ...
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de Korte, Dirk
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Hansen, Morten B ...
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Knutson, Folke
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Transfusion
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Uppsala universitet