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Sökning: onr:"swepub:oai:DiVA.org:uu-208645" > Cystatin C versus C...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003961naa a2200469 4500
001oai:DiVA.org:uu-208645
003SwePub
008131007s2013 | |||||||||||000 ||eng|
009oai:DiVA.org:du-13381
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2086452 URI
0247 a https://doi.org/10.1056/NEJMoa12142342 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:du-133812 URI
040 a (SwePub)uud (SwePub)du
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Shlipak, Michael G.4 aut
2451 0a Cystatin C versus Creatinine in Determining Risk Based on Kidney Function
264 1c 2013
338 a electronic2 rdacarrier
520 a BACKGROUND Adding the measurement of cystatin C to that of serum creatinine to determine the estimated glomerular filtration rate (eGFR) improves accuracy, but the effect on detection, staging, and risk classification of chronic kidney disease across diverse populations has not been determined. METHODS We performed a meta-analysis of 11 general-population studies (with 90,750 participants) and 5 studies of cohorts with chronic kidney disease (2960 participants) for whom standardized measurements of serum creatinine and cystatin C were available. We compared the association of the eGFR, as calculated by the measurement of creatinine or cystatin C alone or in combination with creatinine, with the rates of death (13,202 deaths in 15 cohorts), death from cardiovascular causes (3471 in 12 cohorts), and end-stage renal disease (1654 cases in 7 cohorts) and assessed improvement in reclassification with the use of cystatin C. RESULTS In the general-population cohorts, the prevalence of an eGFR of less than 60 ml per minute per 1.73 m(2) of body-surface area was higher with the cystatin C-based eGFR than with the creatinine-based eGFR (13.7% vs. 9.7%). Across all eGFR categories, the reclassification of the eGFR to a higher value with the measurement of cystatin C, as compared with creatinine, was associated with a reduced risk of all three study outcomes, and reclassification to a lower eGFR was associated with an increased risk. The net reclassification improvement with the measurement of cystatin C, as compared with creatinine, was 0.23 (95% confidence interval [CI], 0.18 to 0.28) for death and 0.10 (95% CI, 0.00 to 0.21) for end-stage renal disease. Results were generally similar for the five cohorts with chronic kidney disease and when both creatinine and cystatin C were used to calculate the eGFR. CONCLUSIONS The use of cystatin C alone or in combination with creatinine strengthens the association between the eGFR and the risks of death and end-stage renal disease across diverse populations.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653 a Hälsa och välfärd
7001 a Matsushita, Kunihiro4 aut
7001 a Ärnlöv, Johanu Högskolan Dalarna,Uppsala universitet,Geriatrik,Medicinsk vetenskap4 aut0 (Swepub:du)jan
7001 a Inker, Lesley A.4 aut
7001 a Katz, Ronit4 aut
7001 a Polkinghorne, Kevan R.4 aut
7001 a Rothenbacher, Dietrich4 aut
7001 a Sarnak, Mark J.4 aut
7001 a Astor, Brad C.4 aut
7001 a Coresh, Josef4 aut
7001 a Levey, Andrew S.4 aut
7001 a Gansevoort, Ron T.4 aut
7102 a Uppsala universitetb Geriatrik4 org
7730 t New England Journal of Medicineg 369:10, s. 932-943q 369:10<932-943x 0028-4793x 1533-4406
8564 u https://uu.diva-portal.org/smash/get/diva2:654033/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-208645
8564 8u https://doi.org/10.1056/NEJMoa1214234
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:du-13381

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