Sökning: onr:"swepub:oai:DiVA.org:uu-210285" > Aerobic capacity at...
Fältnamn | Indikatorer | Metadata |
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000 | 03550naa a2200433 4500 | |
001 | oai:DiVA.org:uu-210285 | |
003 | SwePub | |
008 | 131104s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2102852 URI |
024 | 7 | a https://doi.org/10.1002/lt.237662 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Bernal, William4 aut |
245 | 1 0 | a Aerobic capacity at cardio-pulmonary exercise testing and survival with and without liver transplantation in patients with chronic liver disease |
264 | c 2013-11-29 | |
264 | 1 | b Ovid Technologies (Wolters Kluwer Health),c 2014 |
338 | a print2 rdacarrier | |
520 | a Background: Chronic liver disease (CLD) is associated with muscle wasting, reduced exercise tolerance and aerobic capacity (AC). Measures of AC determined using cardiopulmonary exercise testing (CPET) may predict post liver transplant (LT) survival, but relation to non-transplant outcome is uncertain. In patients assessed for LT we examined the relation of CPET AC parameters to severity of liver disease, nutritional state and survival with and without LT.Patients and Methods:Patients assessed for elective first LT for who underwent CPET and anthropometric assessment at a single centre were studied. CPET-derived measures of AC evaluated were peak oxygen consumption (VO2 -peak) and Anaerobic Threshold (AT).Results:399 patients underwent CPET and 223 LT; 45% of patients had VO2 -peak <50% predicted and 31% AT<9ml/kg/min. VO2 -peak and AT correlated with MELD but more closely with serum sodium and albumin. Hand grip strength correlated strongly with VO2 -peak. Patients with impaired AC had prolonged post-LT hospitalisation and 1-year post-transplantation non-survivors had lower AT than survivors (p<0.05), significant on multivariate analysis. 176 patients did not undergo LT; 1-year mortality was 34.6%. AT (p<0.05) and VO2 -peak (p<0.001) were lower in non-survivors. On multivariate analysis, AT was independently associated with non-survival.Conclusions:Aerobic capacity is markedly impaired in many patients with CLD. In those not transplanted, impaired AT was predictive of mortality and in those undergoing LT related to post-operative hospitalisation and survival. AC should be evaluated as a modifiable factor to improve patient survival, whether or not LT is anticipated. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng |
700 | 1 | a Martin-Mateos, Rosa4 aut |
700 | 1 | a Lipcsey, Miklósu Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)milip123 |
700 | 1 | a Tallis, Caroline4 aut |
700 | 1 | a Woodsford, Kyne4 aut |
700 | 1 | a McPhail, Mark J4 aut |
700 | 1 | a Willars, Christopher4 aut |
700 | 1 | a Auzinger, Georg4 aut |
700 | 1 | a Sizer, Elizabeth4 aut |
700 | 1 | a Heneghan, Michael4 aut |
700 | 1 | a Cottam, Simon4 aut |
700 | 1 | a Heaton, Nigel4 aut |
700 | 1 | a Wendon, Julia4 aut |
710 | 2 | a Uppsala universitetb Anestesiologi och intensivvård4 org |
773 | 0 | t Liver transplantationd : Ovid Technologies (Wolters Kluwer Health)g 20:1, s. 54-62q 20:1<54-62x 1527-6465x 1527-6473 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-210285 |
856 | 4 8 | u https://doi.org/10.1002/lt.23766 |
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