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Molecular mechanism...
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Gonzalez, P.
(författare)
Molecular mechanisms involved in interleukin 1-beta (IL-1 beta)-induced memory impairment. Modulation by alpha-melanocyte-stimulating hormone (alpha-MSH)
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
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Elsevier BV,2013
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-211006
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-211006URI
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https://doi.org/10.1016/j.bbi.2013.08.007DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Pro-inflammatory cytokines can affect cognitive processes such as learning and memory. Particularly, interleukin-1 beta (IL-1 beta) influences the consolidation of hippocampus-dependent memories. We previously reported that administration of IL-1 beta in dorsal hippocampus impaired contextual fear memory consolidation. Different mechanisms have been implicated in the action of IL-1 beta on long-term potentiation (LTP), but the processes by which this inhibition occurs in vivo remain to be elucidated. We herein report that intrahippocampal injection of IL-1 beta induced a significant increase in p38 phosphorylation after contextual fear conditioning. Also, treatment with SB203580, an inhibitor of p38, reversed impairment induced by IL-1 beta on conditioned fear behavior, indicating that this MAPK would be involved in the effect of the cytokine. We also showed that IL-1 beta administration produced a decrease in glutamate release from dorsal hippocampus synaptosomes and that treatment with SB203580 partially reversed this effect. Our results indicated that IL-1 beta-induced impairment in memory consolidation could be mediated by a decrease in glutamate release. This hypothesis is sustained by the fact that treatment with D-cycloserine (DCS), a partial agonist of the NMDA receptor, reversed the effect of IL-1 beta on contextual fear memory. Furthermore, we demonstrated that IL-1 beta produced a temporal delay in ERK phosphorylation and that DCS administration reversed this effect. We also observed that intrahippocampal injection of IL-1 beta decreased BDNF expression after contextual fear conditioning. We previously demonstrated that alpha-MSH reversed the detrimental effect of IL-1 beta on memory consolidation. The present results demonstrate that alpha-MSH administration did not modify the decrease in glutamate release induced by IL-1 beta. However, intrahippocampal injection of alpha-MSH prevented the effect on ERR phosphorylation and BDNF expression induced by IL-1 beta after contextual fear conditioning. Therefore, in the present study we determine possible molecular mechanisms involved in the impairment induced by IL-1 beta on fear memory consolidation. We also established how this effect could be modulated by alpha-MSH.
Ämnesord och genrebeteckningar
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IL-1 beta
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Memory consolidation
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alpha-MSH
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Glutamate release
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p38
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ERK
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BDNF
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Machado, I.
(författare)
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Vilcaes, A.
(författare)
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Caruso, C.
(författare)
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Roth, G. A.
(författare)
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Schiöth, Helgi B.Uppsala universitet,Funktionell farmakologi(Swepub:uu)helgschi
(författare)
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Lasaga, M.
(författare)
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Scimonelli, T.
(författare)
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Uppsala universitetFunktionell farmakologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Brain, behavior, and immunity: Elsevier BV34, s. 141-1500889-15911090-2139
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- Av författaren/redakt...
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Gonzalez, P.
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Machado, I.
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Vilcaes, A.
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Caruso, C.
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Roth, G. A.
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Schiöth, Helgi B ...
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visa fler...
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Lasaga, M.
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Scimonelli, T.
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- Artiklar i publikationen
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Brain, behavior, ...
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Uppsala universitet