Sökning: onr:"swepub:oai:DiVA.org:uu-211018" > Community-wide eval...
Fältnamn | Indikatorer | Metadata |
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000 | 04924naa a2201165 4500 | |
001 | oai:DiVA.org:uu-211018 | |
003 | SwePub | |
008 | 131119s2013 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2110182 URI |
024 | 7 | a https://doi.org/10.1002/prot.243562 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Moretti, Rocco4 aut |
245 | 1 0 | a Community-wide evaluation of methods for predicting the effect of mutations on protein-protein interactions |
264 | c 2013-08-23 | |
264 | 1 | b Wiley,c 2013 |
338 | a print2 rdacarrier | |
520 | a Community-wide blind prediction experiments such as CAPRI and CASP provide an objective measure of the current state of predictive methodology. Here we describe a community-wide assessment of methods to predict the effects of mutations on protein-protein interactions. Twenty-two groups predicted the effects of comprehensive saturation mutagenesis for two designed influenza hemagglutinin binders and the results were compared with experimental yeast display enrichment data obtained using deep sequencing. The most successful methods explicitly considered the effects of mutation on monomer stability in addition to binding affinity, carried out explicit side-chain sampling and backbone relaxation, evaluated packing, electrostatic, and solvation effects, and correctly identified around a third of the beneficial mutations. Much room for improvement remains for even the best techniques, and large-scale fitness landscapes should continue to provide an excellent test bed for continued evaluation of both existing and new prediction methodologies. Proteins 2013; 81:1980-1987. | |
653 | a CAPRI | |
653 | a hemagglutinin | |
653 | a binding | |
653 | a deep mutational scanning | |
653 | a yeast display | |
700 | 1 | a Fleishman, Sarel J.4 aut |
700 | 1 | a Agius, Rudi4 aut |
700 | 1 | a Torchala, Mieczyslaw4 aut |
700 | 1 | a Bates, Paul A.4 aut |
700 | 1 | a Kastritis, Panagiotis L.4 aut |
700 | 1 | a Rodrigues, Joao P. G. L. M.4 aut |
700 | 1 | a Trellet, Mikael4 aut |
700 | 1 | a Bonvin, Alexandre M. J. J.4 aut |
700 | 1 | a Cui, Meng4 aut |
700 | 1 | a Rooman, Marianne4 aut |
700 | 1 | a Gillis, Dimitri4 aut |
700 | 1 | a Dehouck, Yves4 aut |
700 | 1 | a Moal, Iain4 aut |
700 | 1 | a Romero-Durana, Miguel4 aut |
700 | 1 | a Perez-Cano, Laura4 aut |
700 | 1 | a Pallara, Chiara4 aut |
700 | 1 | a Jimenez, Brian4 aut |
700 | 1 | a Fernandez-Recio, Juan4 aut |
700 | 1 | a Flores, Samuelu Uppsala universitet,Beräknings- och systembiologi4 aut0 (Swepub:uu)samfl674 |
700 | 1 | a Pacella, Michael4 aut |
700 | 1 | a Kilambi, Krishna Praneeth4 aut |
700 | 1 | a Gray, Jeffrey J.4 aut |
700 | 1 | a Popov, Petr4 aut |
700 | 1 | a Grudinin, Sergei4 aut |
700 | 1 | a Esquivel-Rodriguez, Juan4 aut |
700 | 1 | a Kihara, Daisuke4 aut |
700 | 1 | a Zhao, Nan4 aut |
700 | 1 | a Korkin, Dmitry4 aut |
700 | 1 | a Zhu, Xiaolei4 aut |
700 | 1 | a Demerdash, Omar N. A.4 aut |
700 | 1 | a Mitchell, Julie C.4 aut |
700 | 1 | a Kanamori, Eiji4 aut |
700 | 1 | a Tsuchiya, Yuko4 aut |
700 | 1 | a Nakamura, Haruki4 aut |
700 | 1 | a Lee, Hasup4 aut |
700 | 1 | a Park, Hahnbeom4 aut |
700 | 1 | a Seok, Chaok4 aut |
700 | 1 | a Sarmiento, Jamica4 aut |
700 | 1 | a Liang, Shide4 aut |
700 | 1 | a Teraguchi, Shusuke4 aut |
700 | 1 | a Standley, Daron M.4 aut |
700 | 1 | a Shimoyama, Hiromitsu4 aut |
700 | 1 | a Terashi, Genki4 aut |
700 | 1 | a Takeda-Shitaka, Mayuko4 aut |
700 | 1 | a Iwadate, Mitsuo4 aut |
700 | 1 | a Umeyama, Hideaki4 aut |
700 | 1 | a Beglov, Dmitri4 aut |
700 | 1 | a Hall, David R.4 aut |
700 | 1 | a Kozakov, Dima4 aut |
700 | 1 | a Vajda, Sandor4 aut |
700 | 1 | a Pierce, Brian G.4 aut |
700 | 1 | a Hwang, Howook4 aut |
700 | 1 | a Vreven, Thom4 aut |
700 | 1 | a Weng, Zhiping4 aut |
700 | 1 | a Huang, Yangyu4 aut |
700 | 1 | a Li, Haotian4 aut |
700 | 1 | a Yang, Xiufeng4 aut |
700 | 1 | a Ji, Xiaofeng4 aut |
700 | 1 | a Liu, Shiyong4 aut |
700 | 1 | a Xiao, Yi4 aut |
700 | 1 | a Zacharias, Martin4 aut |
700 | 1 | a Qin, Sanbo4 aut |
700 | 1 | a Zhou, Huan-Xiang4 aut |
700 | 1 | a Huang, Sheng-You4 aut |
700 | 1 | a Zou, Xiaoqin4 aut |
700 | 1 | a Velankar, Sameer4 aut |
700 | 1 | a Janin, Joel4 aut |
700 | 1 | a Wodak, Shoshana J.4 aut |
700 | 1 | a Baker, David4 aut |
710 | 2 | a Uppsala universitetb Beräknings- och systembiologi4 org |
773 | 0 | t Proteinsd : Wileyg 81:11, s. 1980-1987q 81:11<1980-1987x 0887-3585x 1097-0134 |
856 | 4 | u https://europepmc.org/articles/pmc4143140?pdf=render |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-211018 |
856 | 4 8 | u https://doi.org/10.1002/prot.24356 |
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