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Co-occurring Symptoms of Attention Deficit Hyperactivity Disorder and Depression : Sex, Aetiology, Help-Seeking and Assessment
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- Sonnby, Karin (författare)
- Uppsala universitet,Barn- och ungdomspsykiatri,Centrum för klinisk forskning, Västerås
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- Nilsson, Kent W., professor (preses)
- Centrum för klinisk forskning, Västerås
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- Ramklint, Mia, docent (preses)
- Uppsala universitet,Psykiatri, Akademiska sjukhuset,Uppsala Universitet
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- (creator_code:org_t)
- ISBN 9789155488925
- Uppsala : Acta Universitatis Upsaliensis, 2014
- Engelska 90 s.
- Serie: Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 1651-6206 ; 976
- Doktorsavhandling (övrigt vetenskapligt/konstnärligt)
Abstract
Ämnesord
Stäng
- The general aim of the thesis was to contribute to the knowledge about co-occurring symptoms of ADHD and depression in adolescence, focusing on sex differences, as well as aetiology, help-seeking and assessment.Studies I–III used epidemiological samples of self-reports from all students in Västmanland aged 15–16 and 17–18 years. Study I investigated the prevalence of co-occurring symptoms of ADHD and depression, as well as associations between co-occurring symptoms of ADHD and depression and one environmental stress factor; experience of sexual abuse. Study II examined associations between one biological factor—a polymorphism in TFAP-2β—and co-occurring symptoms of ADHD with andco-occurringsymptoms of depression. Study III investigated the association between the parent–adolescent relationship and seeking help from specialized mental health services in relation to symptoms of ADHD and/or depression. Study IV was a clinical study among adolescent psychiatric patients that compared self-reported ADHD symptoms via the Adult ADHD Self-Report Scale–Adolescent version (ASRS-A) and the Adult ADHD Self-Report Scale–Adolescent–Screening version (ASRS-A-S) with an ADHD diagnosis determined by the gold-standard method; the Kiddie Schedule of Affective Disorders and Schizophrenia diagnostic interview.Studies I–III showed that the phenotype of co-occurring symptoms of ADHD and depression is frequent, with a distinct preponderance among girls. Approximately 50% of both boys and girls with co-occurring symptoms of ADHD and depression had also experienced sexual abuse, indicating that this is a group with multiple risk factors for long-term impaired mental health.Results also support biological sex differences because girls with symptoms of ADHD and a common polymorphism of TFAP-2β (absence of a 9 repeat) reported more symptoms of depression, but boys did not.Further, only 5% of the adolescents with symptoms of ADHD and/or depression sought help from specialized mental health services. The co-occurrence of symptoms of ADHD and depression was a stronger predictor of help-seeking than all other psychosocial factors investigated, including secure attachment cognitions styles to parents. Among help-seeking girls, co-occurring symptoms of ADHD and depression were more common than symptoms of ADHD without co-occurring symptoms of depression.The ASRS-A/ASRS-A-S showed promising psychometric properties for further validation in adolescentsresults as a screening tool for use in adolescents.
Nyckelord
- Attention deficit hyperactivity disorder
- depression
- adolescent
- sex
- sexual abuse
- transcription factor AP-2β
- help-seeking
- attachment object
- validation study
- Child and Youth Psychiatry
- Barn- och ungdomspsykiatri
Publikations- och innehållstyp
- vet (ämneskategori)
- dok (ämneskategori)
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