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Normal oral keratin...
Normal oral keratinocytes and head and neck squamous carcinoma cells induce an innate response in fibroblasts
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- Hakelius, Malin, 1965- (författare)
- Uppsala universitet,Plastikkirurgi
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- Reyhani, Vahid (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Rubin, Kristofer (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Gerdin, Bengt (författare)
- Uppsala universitet,Plastikkirurgi
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- Nowinski, Daniel (författare)
- Uppsala universitet,Plastikkirurgi
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(creator_code:org_t)
- 2016
- 2016
- Engelska.
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Ingår i: Anticancer Research. - 0250-7005 .- 1791-7530. ; 36:5, s. 2131-2137
- Relaterad länk:
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http://ar.iiarjourna...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Tumor stroma is similar to the connective tissue of chronic inflammation. The extracellular matrix of tumors is formed by cancer-associated fibroblasts that also modulate the inflammatory response. Materials and Methods: We studied the ability of oral keratinocytes (NOK) and oral squamous cell carcinoma cells (SCC) to induce an innate immune response in fibroblasts. Co-cultures with fibroblasts in collagen gels and keratinocytes in inserts were used. Pentraxin 3 (PTX3) was used as an indicator of an innate immune response. Results: SCC and NOK up-regulated fibroblast mRNA expression and protein release of PTX3. mRNA levels were more pronounced in cultures with malignant cells. The induction of PTX3 was abrogated by an interleukin-1 receptor antagonist Conclusion: Keratinocytes have the capacity to induce an interleukin-1-dependent innate immune response by fibroblasts in vitro. This could be important for subsequent fibroblast modulation of the inflammatory reaction in non-malignant and malignant disease processes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- co-culture
- pentraxin-3
- extracellular matrix
- interleukin-1 alpha
- tumor stroma
- Plastic Surgery
- Plastikkirurgi
Publikations- och innehållstyp
- vet (ämneskategori)
- art (ämneskategori)
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