No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels

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Fältnamn	Indikatorer	Metadata
000		09053naa a2201693 4500
001		oai:DiVA.org:uu-223046
003		SwePub
008		140416s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:b018f50c-e478-4679-80e3-a9de13827c99
009		oai:DiVA.org:umu-53506
009		oai:prod.swepub.kib.ki.se:124482552
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2230462 URI
024	7	a https://doi.org/10.2337/db11-09732 DOI
024	7	a https://lup.lub.lu.se/record/25630922 URI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-535062 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1244825522 URI
040		a (SwePub)uud (SwePub)lud (SwePub)umud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Scott, Robert A4 aut
245	1 0	a No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels
264		c 2012-04-13
264	1	a Alexandria, VA :b American Diabetes Association,c 2012
338		a print2 rdacarrier
520		a Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (β = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 × 10(-6)). All SNPs were associated with 2-h glucose (β = 0.06-0.12 mmol/allele, P ≤ 1.53 × 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P ≥ 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
700	1	a Chu, Audrey Y4 aut
700	1	a Grarup, Niels4 aut
700	1	a Manning, Alisa K4 aut
700	1	a Hivert, Marie-France4 aut
700	1	a Shungin, Dmitryu Umeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Institutionen för odontologi,Medicin4 aut0 (Swepub:umu)dmsh0003
700	1	a Tönjes, Anke4 aut
700	1	a Yesupriya, Ajay4 aut
700	1	a Barnes, Daniel4 aut
700	1	a Bouatia-Naji, Nabila4 aut
700	1	a Glazer, Nicole L4 aut
700	1	a Jackson, Anne U4 aut
700	1	a Kutalik, Zoltán4 aut
700	1	a Lagou, Vasiliki4 aut
700	1	a Marek, Diana4 aut
700	1	a Rasmussen-Torvik, Laura J4 aut
700	1	a Stringham, Heather M4 aut
700	1	a Tanaka, Toshiko4 aut
700	1	a Aadahl, Mette4 aut
700	1	a Arking, Dan E4 aut
700	1	a Bergmann, Sven4 aut
700	1	a Boerwinkle, Eric4 aut
700	1	a Bonnycastle, Lori L4 aut
700	1	a Bornstein, Stefan R4 aut
700	1	a Brunner, Eric4 aut
700	1	a Bumpstead, Suzannah J4 aut
700	1	a Brage, Soren4 aut
700	1	a Carlson, Olga D4 aut
700	1	a Chen, Han4 aut
700	1	a Chen, Yii-Der Ida4 aut
700	1	a Chines, Peter S4 aut
700	1	a Collins, Francis S4 aut
700	1	a Couper, David J4 aut
700	1	a Dennison, Elaine M4 aut
700	1	a Dowling, Nicole F4 aut
700	1	a Egan, Josephine S4 aut
700	1	a Ekelund, Ulf4 aut
700	1	a Erdos, Michael R4 aut
700	1	a Forouhi, Nita G4 aut
700	1	a Fox, Caroline S4 aut
700	1	a Goodarzi, Mark O4 aut
700	1	a Grässler, Jürgen4 aut
700	1	a Gustafsson, Stefan4 aut
700	1	a Hallmans, Göranu Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001
700	1	a Hansen, Torben4 aut
700	1	a Hingorani, Aroon4 aut
700	1	a Holloway, John W4 aut
700	1	a Hu, Frank B4 aut
700	1	a Isomaa, Bo4 aut
700	1	a Jameson, Karen A4 aut
700	1	a Johansson, Ingegerdu Umeå universitet,Kariologi4 aut0 (Swepub:umu)injo0003
700	1	a Jonsson, Annau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)med-jsa
700	1	a Jørgensen, Torben4 aut
700	1	a Kivimaki, Mika4 aut
700	1	a Kovacs, Peter4 aut
700	1	a Kumari, Meena4 aut
700	1	a Kuusisto, Johanna4 aut
700	1	a Laakso, Markku4 aut
700	1	a Lecoeur, Cécile4 aut
700	1	a Lévy-Marchal, Claire4 aut
700	1	a Li, Guo4 aut
700	1	a Loos, Ruth J F4 aut
700	1	a Lyssenko, Valeriyau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-vly
700	1	a Marmot, Michael4 aut
700	1	a Marques-Vidal, Pedro4 aut
700	1	a Morken, Mario A4 aut
700	1	a Müller, Gabriele4 aut
700	1	a North, Kari E4 aut
700	1	a Pankow, James S4 aut
700	1	a Payne, Felicity4 aut
700	1	a Prokopenko, Inga4 aut
700	1	a Psaty, Bruce M4 aut
700	1	a Renström, Fridau Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-frm
700	1	a Rice, Ken4 aut
700	1	a Rotter, Jerome I4 aut
700	1	a Rybin, Denis4 aut
700	1	a Sandholt, Camilla H4 aut
700	1	a Sayer, Avan A4 aut
700	1	a Shrader, Peter4 aut
700	1	a Schwarz, Peter E H4 aut
700	1	a Siscovick, David S4 aut
700	1	a Stancáková, Alena4 aut
700	1	a Stumvoll, Michael4 aut
700	1	a Teslovich, Tanya M4 aut
700	1	a Waeber, Gérard4 aut
700	1	a Williams, Gordon H4 aut
700	1	a Witte, Daniel R4 aut
700	1	a Wood, Andrew R4 aut
700	1	a Xie, Weijia4 aut
700	1	a Boehnke, Michael4 aut
700	1	a Cooper, Cyrus4 aut
700	1	a Ferrucci, Luigi4 aut
700	1	a Froguel, Philippe4 aut
700	1	a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr
700	1	a Kao, W H Linda4 aut
700	1	a Vollenweider, Peter4 aut
700	1	a Walker, Mark4 aut
700	1	a Watanabe, Richard M4 aut
700	1	a Pedersen, Oluf4 aut
700	1	a Meigs, James B4 aut
700	1	a Ingelsson, Erik,d 1975-u Karolinska Institutet4 aut0 (Swepub:uu)ering425
700	1	a Barroso, Inês4 aut
700	1	a Florez, Jose C4 aut
700	1	a Franks, Paulu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology4 aut0 (Swepub:lu)med-plf
700	1	a Dupuis, Josée4 aut
700	1	a Wareham, Nicholas J4 aut
700	1	a Langenberg, Claudia4 aut
710	2	a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org
773	0	t Diabetesd Alexandria, VA : American Diabetes Associationg 61:5, s. 1291-1296q 61:5<1291-1296x 0012-1797x 1939-327X
856	4	u https://diabetes.diabetesjournals.org/content/diabetes/61/5/1291.full.pdf
856	4	u http://dx.doi.org/10.2337/db11-0973y FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-223046
856	4 8	u https://doi.org/10.2337/db11-0973
856	4 8	u https://lup.lub.lu.se/record/2563092
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-53506
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:124482552

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Av författaren/redakt...: Scott, Robert A; Chu, Audrey Y; Grarup, Niels; Manning, Alisa K; Hivert, Marie-Fr ...; Shungin, Dmitry; visa fler...; Tönjes, Anke; Yesupriya, Ajay; Barnes, Daniel; Bouatia-Naji, Na ...; Glazer, Nicole L; Jackson, Anne U; Kutalik, Zoltán; Lagou, Vasiliki; Marek, Diana; Rasmussen-Torvik ...; Stringham, Heath ...; Tanaka, Toshiko; Aadahl, Mette; Arking, Dan E; Bergmann, Sven; Boerwinkle, Eric; Bonnycastle, Lor ...; Bornstein, Stefa ...; Brunner, Eric; Bumpstead, Suzan ...; Brage, Soren; Carlson, Olga D; Chen, Han; Chen, Yii-Der Id ...; Chines, Peter S; Collins, Francis ...; Couper, David J; Dennison, Elaine ...; Dowling, Nicole ...; Egan, Josephine ...; Ekelund, Ulf; Erdos, Michael R; Forouhi, Nita G; Fox, Caroline S; Goodarzi, Mark O; Grässler, Jürgen; Gustafsson, Stef ...; Hallmans, Göran; Hansen, Torben; Hingorani, Aroon; Holloway, John W; Hu, Frank B; Isomaa, Bo; Jameson, Karen A; Johansson, Ingeg ...; Jonsson, Anna; Jørgensen, Torbe ...; Kivimaki, Mika; Kovacs, Peter; Kumari, Meena; Kuusisto, Johann ...; Laakso, Markku; Lecoeur, Cécile; Lévy-Marchal, Cl ...; Li, Guo; Loos, Ruth J F; Lyssenko, Valeri ...; Marmot, Michael; Marques-Vidal, P ...; Morken, Mario A; Müller, Gabriele; North, Kari E; Pankow, James S; Payne, Felicity; Prokopenko, Inga; Psaty, Bruce M; Renström, Frida; Rice, Ken; Rotter, Jerome I; Rybin, Denis; Sandholt, Camill ...; Sayer, Avan A; Shrader, Peter; Schwarz, Peter E ...; Siscovick, David ...; Stancáková, Alen ...; Stumvoll, Michae ...; Teslovich, Tanya ...; Waeber, Gérard; Williams, Gordon ...; Witte, Daniel R; Wood, Andrew R; Xie, Weijia; Boehnke, Michael; Cooper, Cyrus; Ferrucci, Luigi; Froguel, Philipp ...; Groop, Leif; Kao, W H Linda; Vollenweider, Pe ...; Walker, Mark; Watanabe, Richar ...; Pedersen, Oluf; Meigs, James B; Ingelsson, Erik, ...; Barroso, Inês; Florez, Jose C; Franks, Paul; Dupuis, Josée; Wareham, Nichola ...; Langenberg, Clau ...; visa färre...

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