Sökning: onr:"swepub:oai:DiVA.org:uu-224752" > Telomere length in ...
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000 | 05212naa a2200901 4500 | |
001 | oai:DiVA.org:uu-224752 | |
003 | SwePub | |
008 | 140519s2014 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:128687236 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2247522 URI |
024 | 7 | a https://doi.org/10.1183/09031936.000462132 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1286872362 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Albrecht, Eva4 aut |
245 | 1 0 | a Telomere length in circulating leukocytes is associated with lung function and disease |
264 | c 2013-12-05 | |
264 | 1 | b European Respiratory Society (ERS),c 2014 |
338 | a print2 rdacarrier | |
520 | a Several clinical studies suggest the involvement of premature ageing processes in chronic obstructive pulmonary disease (COPD). Using an epidemiological approach, we studied whether accelerated ageing indicated by telomere length, a marker of biological age, is associated with COPD and asthma, and whether intrinsic age-related processes contribute to the interindividual variability of lung function. Our meta-analysis of 14 studies included 934 COPD cases with 15 846 controls defined according to the Global Lungs Initiative (GLI) criteria (or 1189 COPD cases according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria), 2834 asthma cases with 28 195 controls, and spirometric parameters (forced expiratory volume in is (FEV1), forced vital capacity (PVC) and FEV1/FVC) of 12 595 individuals. Associations with telomere length were tested by linear regression, adjusting for age, sex and smoking status. We observed negative associations between telomere length and asthma (beta= -0.0452, p= 0.024) as well as COPD (beta= -0.0982, p=0.001), with associations being stronger and more significant when using GLI criteria than those of GOLD. In both diseases, effects were stronger in females than males. The investigation of spirometric indices showed positive associations between telomere length and FEV1 (p=1.07 x 10(-7)), FVC (p=2.07 x 10(-5)), and FEV1/FVC (p =5.27 x 10(-3)). The effect was somewhat weaker in apparently healthy subjects than in COPD or asthma patients. Our results provide indirect evidence for the hypothesis that cellular senescence may contribute to the pathogenesis of COPD and asthma, and that lung function may reflect biological ageing primarily due to intrinsic processes, which are likely to be aggravated in lung diseases. | |
700 | 1 | a Sillanpaa, Elina4 aut |
700 | 1 | a Karrasch, Stefan4 aut |
700 | 1 | a Alves, Alexessander Couto4 aut |
700 | 1 | a Codd, Veryan4 aut |
700 | 1 | a Hovatta, Iiris4 aut |
700 | 1 | a Buxton, Jessica L.4 aut |
700 | 1 | a Nelson, Christopher P.4 aut |
700 | 1 | a Broer, Linda4 aut |
700 | 1 | a Hägg, Sarau Karolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)sarha464 |
700 | 1 | a Mangino, Massimo4 aut |
700 | 1 | a Willemsen, Gonneke4 aut |
700 | 1 | a Surakka, Ida4 aut |
700 | 1 | a Ferreira, Manuel A. R.4 aut |
700 | 1 | a Amin, Najaf4 aut |
700 | 1 | a Oostra, Ben A.4 aut |
700 | 1 | a Backmand, Hell M.4 aut |
700 | 1 | a Peltonen, Markku4 aut |
700 | 1 | a Sarna, Seppo4 aut |
700 | 1 | a Rantanen, Taina4 aut |
700 | 1 | a Sipila, Sarianna4 aut |
700 | 1 | a Korhonen, Tellervo4 aut |
700 | 1 | a Madden, Pamela A. F.4 aut |
700 | 1 | a Gieger, Christian4 aut |
700 | 1 | a Jorres, Rudolf A.4 aut |
700 | 1 | a Heinrich, Joachim4 aut |
700 | 1 | a Behr, Juergen4 aut |
700 | 1 | a Huber, Rudolf M.4 aut |
700 | 1 | a Peters, Annette4 aut |
700 | 1 | a Strauch, Konstantin4 aut |
700 | 1 | a Wichmann, H. Erich4 aut |
700 | 1 | a Waldenberger, Melanie4 aut |
700 | 1 | a Blakemore, Alexandra I. F.4 aut |
700 | 1 | a de Geus, Eco J. C.4 aut |
700 | 1 | a Nyholt, Dale R.4 aut |
700 | 1 | a Henders, Anjali K.4 aut |
700 | 1 | a Piirila, Paeivi L.4 aut |
700 | 1 | a Rissanen, Aila4 aut |
700 | 1 | a Magnusson, Patrik K. E.u Karolinska Institutet4 aut |
700 | 1 | a Vinuela, Ana4 aut |
700 | 1 | a Pietilainen, Kirsi H.4 aut |
700 | 1 | a Martin, Nicholas G.4 aut |
700 | 1 | a Pedersen, Nancy L.u Karolinska Institutet4 aut |
700 | 1 | a Boomsma, Dorret I.4 aut |
700 | 1 | a Spector, Tim D.4 aut |
700 | 1 | a van Duijn, Cornelia M.4 aut |
700 | 1 | a Kaprio, Jaakko4 aut |
700 | 1 | a Samani, Nilesh J.4 aut |
700 | 1 | a Jarvelin, Marjo-Riitta4 aut |
700 | 1 | a Schulz, Holger4 aut |
710 | 2 | a Uppsala universitetb Molekylär epidemiologi4 org |
773 | 0 | t European Respiratory Journald : European Respiratory Society (ERS)g 43:4, s. 983-992q 43:4<983-992x 0903-1936x 1399-3003 |
856 | 4 | u https://erj.ersjournals.com/content/erj/43/4/983.full.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-224752 |
856 | 4 8 | u https://doi.org/10.1183/09031936.00046213 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:128687236 |
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