Telomere length in circulating leukocytes is associated with lung function and disease

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Fältnamn	Indikatorer	Metadata
000		05212naa a2200901 4500
001		oai:DiVA.org:uu-224752
003		SwePub
008		140519s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:128687236
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2247522 URI
024	7	a https://doi.org/10.1183/09031936.000462132 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1286872362 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Albrecht, Eva4 aut
245	1 0	a Telomere length in circulating leukocytes is associated with lung function and disease
264		c 2013-12-05
264	1	b European Respiratory Society (ERS),c 2014
338		a print2 rdacarrier
520		a Several clinical studies suggest the involvement of premature ageing processes in chronic obstructive pulmonary disease (COPD). Using an epidemiological approach, we studied whether accelerated ageing indicated by telomere length, a marker of biological age, is associated with COPD and asthma, and whether intrinsic age-related processes contribute to the interindividual variability of lung function. Our meta-analysis of 14 studies included 934 COPD cases with 15 846 controls defined according to the Global Lungs Initiative (GLI) criteria (or 1189 COPD cases according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria), 2834 asthma cases with 28 195 controls, and spirometric parameters (forced expiratory volume in is (FEV1), forced vital capacity (PVC) and FEV1/FVC) of 12 595 individuals. Associations with telomere length were tested by linear regression, adjusting for age, sex and smoking status. We observed negative associations between telomere length and asthma (beta= -0.0452, p= 0.024) as well as COPD (beta= -0.0982, p=0.001), with associations being stronger and more significant when using GLI criteria than those of GOLD. In both diseases, effects were stronger in females than males. The investigation of spirometric indices showed positive associations between telomere length and FEV1 (p=1.07 x 10(-7)), FVC (p=2.07 x 10(-5)), and FEV1/FVC (p =5.27 x 10(-3)). The effect was somewhat weaker in apparently healthy subjects than in COPD or asthma patients. Our results provide indirect evidence for the hypothesis that cellular senescence may contribute to the pathogenesis of COPD and asthma, and that lung function may reflect biological ageing primarily due to intrinsic processes, which are likely to be aggravated in lung diseases.
700	1	a Sillanpaa, Elina4 aut
700	1	a Karrasch, Stefan4 aut
700	1	a Alves, Alexessander Couto4 aut
700	1	a Codd, Veryan4 aut
700	1	a Hovatta, Iiris4 aut
700	1	a Buxton, Jessica L.4 aut
700	1	a Nelson, Christopher P.4 aut
700	1	a Broer, Linda4 aut
700	1	a Hägg, Sarau Karolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)sarha464
700	1	a Mangino, Massimo4 aut
700	1	a Willemsen, Gonneke4 aut
700	1	a Surakka, Ida4 aut
700	1	a Ferreira, Manuel A. R.4 aut
700	1	a Amin, Najaf4 aut
700	1	a Oostra, Ben A.4 aut
700	1	a Backmand, Hell M.4 aut
700	1	a Peltonen, Markku4 aut
700	1	a Sarna, Seppo4 aut
700	1	a Rantanen, Taina4 aut
700	1	a Sipila, Sarianna4 aut
700	1	a Korhonen, Tellervo4 aut
700	1	a Madden, Pamela A. F.4 aut
700	1	a Gieger, Christian4 aut
700	1	a Jorres, Rudolf A.4 aut
700	1	a Heinrich, Joachim4 aut
700	1	a Behr, Juergen4 aut
700	1	a Huber, Rudolf M.4 aut
700	1	a Peters, Annette4 aut
700	1	a Strauch, Konstantin4 aut
700	1	a Wichmann, H. Erich4 aut
700	1	a Waldenberger, Melanie4 aut
700	1	a Blakemore, Alexandra I. F.4 aut
700	1	a de Geus, Eco J. C.4 aut
700	1	a Nyholt, Dale R.4 aut
700	1	a Henders, Anjali K.4 aut
700	1	a Piirila, Paeivi L.4 aut
700	1	a Rissanen, Aila4 aut
700	1	a Magnusson, Patrik K. E.u Karolinska Institutet4 aut
700	1	a Vinuela, Ana4 aut
700	1	a Pietilainen, Kirsi H.4 aut
700	1	a Martin, Nicholas G.4 aut
700	1	a Pedersen, Nancy L.u Karolinska Institutet4 aut
700	1	a Boomsma, Dorret I.4 aut
700	1	a Spector, Tim D.4 aut
700	1	a van Duijn, Cornelia M.4 aut
700	1	a Kaprio, Jaakko4 aut
700	1	a Samani, Nilesh J.4 aut
700	1	a Jarvelin, Marjo-Riitta4 aut
700	1	a Schulz, Holger4 aut
710	2	a Uppsala universitetb Molekylär epidemiologi4 org
773	0	t European Respiratory Journald : European Respiratory Society (ERS)g 43:4, s. 983-992q 43:4<983-992x 0903-1936x 1399-3003
856	4	u https://erj.ersjournals.com/content/erj/43/4/983.full.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-224752
856	4 8	u https://doi.org/10.1183/09031936.00046213
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:128687236

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Av författaren/redakt...: Albrecht, Eva; Sillanpaa, Elina; Karrasch, Stefan; Alves, Alexessan ...; Codd, Veryan; Hovatta, Iiris; visa fler...; Buxton, Jessica ...; Nelson, Christop ...; Broer, Linda; Hägg, Sara; Mangino, Massimo; Willemsen, Gonne ...; Surakka, Ida; Ferreira, Manuel ...; Amin, Najaf; Oostra, Ben A.; Backmand, Hell M ...; Peltonen, Markku; Sarna, Seppo; Rantanen, Taina; Sipila, Sarianna; Korhonen, Teller ...; Madden, Pamela A ...; Gieger, Christia ...; Jorres, Rudolf A ...; Heinrich, Joachi ...; Behr, Juergen; Huber, Rudolf M.; Peters, Annette; Strauch, Konstan ...; Wichmann, H. Eri ...; Waldenberger, Me ...; Blakemore, Alexa ...; de Geus, Eco J. ...; Nyholt, Dale R.; Henders, Anjali ...; Piirila, Paeivi ...; Rissanen, Aila; Magnusson, Patri ...; Vinuela, Ana; Pietilainen, Kir ...; Martin, Nicholas ...; Pedersen, Nancy ...; Boomsma, Dorret ...; Spector, Tim D.; van Duijn, Corne ...; Kaprio, Jaakko; Samani, Nilesh J ...; Jarvelin, Marjo- ...; Schulz, Holger; visa färre...

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