Sökning: onr:"swepub:oai:DiVA.org:uu-22629" >
Release of sequeste...
Release of sequestered malaria parasites upon injection of a glycosaminoglycan
-
Vogt, Anna M. (författare)
-
- Pettersson, Fredrik (författare)
- Karolinska Institutet
-
- Moll, Kirsten (författare)
- Karolinska Institutet
-
visa fler...
-
Jonsson, Cathrine (författare)
-
Normark, Johan (författare)
-
- Ribacke, Ulf (författare)
- Karolinska Institutet
-
Egwang, Thomas G. (författare)
-
Ekre, Hans-Peter (författare)
-
- Spillmann, Dorothe (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
-
Chen, Qijun (författare)
-
- Wahlgren, Mats (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- 2006-09-29
- 2006
- Engelska.
-
Ingår i: PLoS Pathogens. - : Public Library of Science (PLoS). - 1553-7366 .- 1553-7374. ; 2:9, s. 853-863
- Relaterad länk:
-
https://journals.plo...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Severe human malaria is attributable to an excessive sequestration of Plasmodium falciparum-infected and uninfected erythrocytes in vital organs. Strains of P. falciparum that form rosettes and employ heparan sulfate as a host receptor are associated with development of severe forms of malaria. Heparin, which is similar to heparan sulfate in that it is composed of the same building blocks, was previously used in the treatment of severe malaria, but it was discontinued due to the occurrence of serious side effects such as intracranial bleedings. Here we report to have depolymerized heparin by periodate treatment to generate novel glycans (dGAG) that lack anticoagulant-activity. The dGAGs disrupt rosettes, inhibit merozoite invasion of erythrocytes and endothelial binding of P. falciparum-infected erythrocytes in vitro, and reduce sequestration in in vivo models of severe malaria. An intravenous injection of dGAGs blocks up to 80% of infected erythrocytes from binding in the micro-vasculature of the rat and releases already sequestered parasites into circulation. P. falciparum-infected human erythrocytes that sequester in the non-human primate Macaca fascicularis were similarly found to be released in to the circulation upon a single injection of 500 mu g of dGAG. We suggest dGAGs to be promising candidates for adjunct therapy in severe malaria.
Nyckelord
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Vogt, Anna M.
-
Pettersson, Fred ...
-
Moll, Kirsten
-
Jonsson, Cathrin ...
-
Normark, Johan
-
Ribacke, Ulf
-
visa fler...
-
Egwang, Thomas G ...
-
Ekre, Hans-Peter
-
Spillmann, Dorot ...
-
Chen, Qijun
-
Wahlgren, Mats
-
visa färre...
- Artiklar i publikationen
-
PLoS Pathogens
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet