Sökning: onr:"swepub:oai:DiVA.org:uu-227996" > In vivo methods for...
Fältnamn | Indikatorer | Metadata |
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000 | 03505naa a2200637 4500 | |
001 | oai:DiVA.org:uu-227996 | |
003 | SwePub | |
008 | 140702s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2279962 URI |
024 | 7 | a https://doi.org/10.1016/j.ejps.2014.02.0102 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Sjögren, Eriku Uppsala universitet,Institutionen för farmaci4 aut0 (Swepub:uu)ersjo473 |
245 | 1 0 | a In vivo methods for drug absorption - Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects |
264 | 1 | b Elsevier BV,c 2014 |
338 | a print2 rdacarrier | |
520 | a This review summarizes the current knowledge on anatomy and physiology of the human gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and mouse) with emphasis on in vivo methods for testing and prediction of oral dosage form performance. A wide range of factors and methods are considered in addition, such as imaging methods, perfusion models, models for predicting segmental/regional absorption, in vitro in vivo correlations as well as models to investigate the effects of excipients and the role of food on drug absorption. One goal of the authors was to clearly identify the gaps in today's knowledge in order to stimulate further work on refining the existing in vivo models and demonstrate their usefulness in drug formulation and product performance testing. (c) 2014 Elsevier B.V. All rights reserved. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng |
653 | a In vivo model selection | |
653 | a Biopharmaceutic characterization | |
653 | a Bioavailability | |
653 | a Drug product development | |
700 | 1 | a Abrahamsson, Bertil4 aut |
700 | 1 | a Augustijns, Patrick4 aut |
700 | 1 | a Becker, Dieter4 aut |
700 | 1 | a Bolger, Michael B.4 aut |
700 | 1 | a Brewster, Marcus4 aut |
700 | 1 | a Brouwers, Joachim4 aut |
700 | 1 | a Flanagan, Talia4 aut |
700 | 1 | a Harwood, Matthew4 aut |
700 | 1 | a Heinen, Christian4 aut |
700 | 1 | a Holm, Rene4 aut |
700 | 1 | a Juretschke, Hans-Paul4 aut |
700 | 1 | a Kubbinga, Marlies4 aut |
700 | 1 | a Lindahl, Anders4 aut |
700 | 1 | a Lukacova, Viera4 aut |
700 | 1 | a Munster, Uwe4 aut |
700 | 1 | a Neuhoff, Sibylle4 aut |
700 | 1 | a Nguyen, Mai Anh4 aut |
700 | 1 | a van Peer, Achiel4 aut |
700 | 1 | a Reppas, Christos4 aut |
700 | 1 | a Hodjegan, Amin Rostami4 aut |
700 | 1 | a Tannergren, Christer4 aut |
700 | 1 | a Weitschies, Werner4 aut |
700 | 1 | a Wilson, Clive4 aut |
700 | 1 | a Zane, Patricia4 aut |
700 | 1 | a Lennernäs, Hansu Uppsala universitet,Institutionen för farmaci4 aut0 (Swepub:uu)hanslenn |
700 | 1 | a Langguth, Peter4 aut |
710 | 2 | a Uppsala universitetb Institutionen för farmaci4 org |
773 | 0 | t European Journal of Pharmaceutical Sciencesd : Elsevier BVg 57, s. 99-151q 57<99-151x 0928-0987x 1879-0720 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-227996 |
856 | 4 8 | u https://doi.org/10.1016/j.ejps.2014.02.010 |
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