Sökning: onr:"swepub:oai:DiVA.org:uu-228008" > Genetic determinant...
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000 | 10263naa a2202077 4500 | |
001 | oai:DiVA.org:uu-228008 | |
003 | SwePub | |
008 | 140702s2014 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:fb63a1c4-6c5f-4f66-b206-467c0a908ace | |
009 | oai:gup.ub.gu.se/199781 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2280082 URI |
024 | 7 | a https://doi.org/10.1093/hmg/ddt6752 DOI |
024 | 7 | a https://lup.lub.lu.se/record/45524862 URI |
024 | 7 | a https://gup.ub.gu.se/publication/1997812 URI |
040 | a (SwePub)uud (SwePub)lud (SwePub)gu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Moayyeri, Alireza4 aut |
245 | 1 0 | a Genetic determinants of heel bone properties :b genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium |
264 | c 2014-01-14 | |
264 | 1 | b Oxford University Press (OUP),c 2014 |
338 | a print2 rdacarrier | |
520 | a Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n = 14 260), velocity of sound (VOS; n = 15 514) and BMD (n = 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (in silico n = 11 452) and new genotyping in 15 cohorts (de novo n = 24 902). In combined random effects, meta-analysis of the discovery and replication cohorts, nine single nucleotide polymorphisms (SNPs) had genome-wide significant (P < 5 x 10(-8)) associations with heel bone properties. Alongside SNPs within or near previously identified osteoporosis susceptibility genes including ESR1 (6q25.1: rs4869739, rs3020331, rs2982552), SPTBN1 (2p16.2: rs11898505), RSPO3 (6q22.33: rs7741021), WNT16 (7q31.31: rs2908007), DKK1 (10q21.1: rs7902708) and GPATCH1 (19q13.11: rs10416265), we identified a new locus on chromosome 11q14.2 (rs597319 close to TMEM135, a gene recently linked to osteoblastogenesis and longevity) significantly associated with both BUA and VOS (P < 8.23 x 10(-14)). In meta-analyses involving 25 cohorts with up to 14 985 fracture cases, six of 10 SNPs associated with heel bone properties at P < 5 x 10(-6) also had the expected direction of association with any fracture (P < 0.05), including three SNPs with P < 0.005: 6q22.33 (rs7741021), 7q31.31 (rs2908007) and 10q21.1 (rs7902708). In conclusion, this GWA study reveals the effect of several genes common to central DXA-derived BMD and heel ultrasound/DXA measures and points to a new genetic locus with potential implications for better understanding of osteoporosis pathophysiology. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
653 | a X-RAY ABSORPTIOMETRY | |
653 | a QUANTITATIVE ULTRASOUND | |
653 | a MINERAL DENSITY | |
653 | a OSTEOPOROSIS | |
653 | a FRACTURE | |
653 | a RISK | |
653 | a DENSITOMETRY | |
653 | a PHENOTYPES | |
653 | a CALCANEUS | |
653 | a WOMEN | |
700 | 1 | a Hsu, Yi-Hsiang4 aut |
700 | 1 | a Karasik, David4 aut |
700 | 1 | a Estrada, Karol4 aut |
700 | 1 | a Xiao, Su-Mei4 aut |
700 | 1 | a Nielson, Carrie4 aut |
700 | 1 | a Srikanth, Priya4 aut |
700 | 1 | a Giroux, Sylvie4 aut |
700 | 1 | a Wilson, Scott G.4 aut |
700 | 1 | a Zheng, Hou-Feng4 aut |
700 | 1 | a Smith, Albert V.4 aut |
700 | 1 | a Pye, Stephen R.4 aut |
700 | 1 | a Leo, Paul J.4 aut |
700 | 1 | a Teumer, Alexander4 aut |
700 | 1 | a Hwang, Joo-Yeon4 aut |
700 | 1 | a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xohlcl |
700 | 1 | a McGuigan, Fionau Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups4 aut0 (Swepub:lu)med-fam |
700 | 1 | a Minster, Ryan L.4 aut |
700 | 1 | a Hayward, Caroline4 aut |
700 | 1 | a Olmos, Jose M.4 aut |
700 | 1 | a Lyytikaeinen, Leo-Pekka4 aut |
700 | 1 | a Lewis, Joshua R.4 aut |
700 | 1 | a Swart, Karin M. A.4 aut |
700 | 1 | a Masi, Laura4 aut |
700 | 1 | a Oldmeadow, Chris4 aut |
700 | 1 | a Holliday, Elizabeth G.4 aut |
700 | 1 | a Cheng, Sulin4 aut |
700 | 1 | a Mellström, Dan,d 1945u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xmelda |
700 | 1 | a Harvey, Nicholas C.4 aut |
700 | 1 | a Kruk, Marcin4 aut |
700 | 1 | a Fabiola Del Greco, M.4 aut |
700 | 1 | a Igl, Wilmar4 aut |
700 | 1 | a Trummer, Olivia4 aut |
700 | 1 | a Grigoriou, Efi4 aut |
700 | 1 | a Luben, Robert4 aut |
700 | 1 | a Liu, Ching-Ti4 aut |
700 | 1 | a Zhou, Yanhua4 aut |
700 | 1 | a Oei, Ling4 aut |
700 | 1 | a Medina-Gomez, Carolina4 aut |
700 | 1 | a Zmuda, Joseph4 aut |
700 | 1 | a Tranah, Greg4 aut |
700 | 1 | a Brown, Suzanne J.4 aut |
700 | 1 | a Williams, Frances M.4 aut |
700 | 1 | a Soranzo, Nicole4 aut |
700 | 1 | a Jakobsdottir, Johanna4 aut |
700 | 1 | a Siggeirsdottir, Kristin4 aut |
700 | 1 | a Holliday, Kate L.4 aut |
700 | 1 | a Hannemann, Anke4 aut |
700 | 1 | a Go, Min Jin4 aut |
700 | 1 | a Garcia, Melissa4 aut |
700 | 1 | a Polasek, Ozren4 aut |
700 | 1 | a Laaksonen, Marika4 aut |
700 | 1 | a Zhu, Kun4 aut |
700 | 1 | a Enneman, Anke W.4 aut |
700 | 1 | a McEvoy, Mark4 aut |
700 | 1 | a Peel, Roseanne4 aut |
700 | 1 | a Sham, Pak Chung4 aut |
700 | 1 | a Jaworski, Maciej4 aut |
700 | 1 | a Johansson, Asa4 aut |
700 | 1 | a Hicks, Andrew A.4 aut |
700 | 1 | a Pludowski, Pawel4 aut |
700 | 1 | a Scott, Rodney4 aut |
700 | 1 | a Dhonukshe-Rutten, Rosalie A. M.4 aut |
700 | 1 | a van der Velde, Nathalie4 aut |
700 | 1 | a Kaehoenen, Mika4 aut |
700 | 1 | a Viikari, Jorma S.4 aut |
700 | 1 | a Sievaenen, Harri4 aut |
700 | 1 | a Raitakari, Olli T.4 aut |
700 | 1 | a Gonzalez-Macias, Jesus4 aut |
700 | 1 | a Hernandez, Jose L.4 aut |
700 | 1 | a Mellstroem, Dan4 aut |
700 | 1 | a Ljunggren, Östenu Uppsala universitet,Endokrinologi och mineralmetabolism4 aut0 (Swepub:uu)osteljun |
700 | 1 | a Cho, Yoon Shin4 aut |
700 | 1 | a Voelker, Uwe4 aut |
700 | 1 | a Nauck, Matthias4 aut |
700 | 1 | a Homuth, Georg4 aut |
700 | 1 | a Voelzke, Henry4 aut |
700 | 1 | a Haring, Robin4 aut |
700 | 1 | a Brown, Matthew A.4 aut |
700 | 1 | a McCloskey, Eugene4 aut |
700 | 1 | a Nicholson, Geoffrey C.4 aut |
700 | 1 | a Eastell, Richard4 aut |
700 | 1 | a Eisman, John A.4 aut |
700 | 1 | a Jones, Graeme4 aut |
700 | 1 | a Reid, Ian R.4 aut |
700 | 1 | a Dennison, Elaine M.4 aut |
700 | 1 | a Wark, John4 aut |
700 | 1 | a Boonen, Steven4 aut |
700 | 1 | a Vanderschueren, Dirk4 aut |
700 | 1 | a Wu, Frederick C. W.4 aut |
700 | 1 | a Aspelund, Thor4 aut |
700 | 1 | a Richards, J. Brent4 aut |
700 | 1 | a Bauer, Doug4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Dedoussis, George4 aut |
700 | 1 | a Obermayer-Pietsch, Barbara4 aut |
700 | 1 | a Gyllensten, Ulf4 aut |
700 | 1 | a Pramstaller, Peter P.4 aut |
700 | 1 | a Lorenc, Roman S.4 aut |
700 | 1 | a Cooper, Cyrus4 aut |
700 | 1 | a Kung, Annie Wai Chee4 aut |
700 | 1 | a Lips, Paul4 aut |
700 | 1 | a Alen, Markku4 aut |
700 | 1 | a Attia, John4 aut |
700 | 1 | a Luisa Brandi, Maria4 aut |
700 | 1 | a de Groot, Lisette C. P. G. M.4 aut |
700 | 1 | a Lehtimaeki, Terho4 aut |
700 | 1 | a Riancho, Jose A.4 aut |
700 | 1 | a Campbell, Harry4 aut |
700 | 1 | a Liu, Yongmei4 aut |
700 | 1 | a Harris, Tamara B.4 aut |
700 | 1 | a Åkesson, Kristinau Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups4 aut0 (Swepub:lu)orto-kak |
700 | 1 | a Karlsson, Magnusu Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups4 aut0 (Swepub:lu)orto-mka |
700 | 1 | a Lee, Jong-Young4 aut |
700 | 1 | a Wallaschofski, Henri4 aut |
700 | 1 | a Duncan, Emma L.4 aut |
700 | 1 | a O'Neill, Terence W.4 aut |
700 | 1 | a Gudnason, Vilmundur4 aut |
700 | 1 | a Spector, Timothy D.4 aut |
700 | 1 | a Rousseau, Francois4 aut |
700 | 1 | a Orwoll, Eric4 aut |
700 | 1 | a Cummings, Steven R.4 aut |
700 | 1 | a Wareham, Nick J.4 aut |
700 | 1 | a Rivadeneira, Fernando4 aut |
700 | 1 | a Uitterlinden, Andre G.4 aut |
700 | 1 | a Prince, Richard L.4 aut |
700 | 1 | a Kiel, Douglas P.4 aut |
700 | 1 | a Reeve, Jonathan4 aut |
700 | 1 | a Kaptoge, Stephen K.4 aut |
710 | 2 | a Göteborgs universitetb Centre for Bone and Arthritis Research4 org |
773 | 0 | t Human Molecular Geneticsd : Oxford University Press (OUP)g 23:11, s. 3054-3068q 23:11<3054-3068x 0964-6906x 1460-2083 |
856 | 4 | u https://academic.oup.com/hmg/article-pdf/23/11/3054/13917531/ddt675.pdf |
856 | 4 | u http://dx.doi.org/10.1093/hmg/ddt675x freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-228008 |
856 | 4 8 | u https://doi.org/10.1093/hmg/ddt675 |
856 | 4 8 | u https://lup.lub.lu.se/record/4552486 |
856 | 4 8 | u https://gup.ub.gu.se/publication/199781 |
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