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Sökning: onr:"swepub:oai:DiVA.org:uu-228031" > Children with juven...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03029naa a2200373 4500 | |
| 001 | oai:DiVA.org:uu-228031 | |
| 003 | SwePub | |
| 008 | 140702s2014 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2280312 URI |
| 024 | 7 | a https://doi.org/10.1111/apa.125562 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Kazamia, Kalliopiu Uppsala universitet,Pediatrik4 aut0 (Swepub:uu)kalka805 |
| 245 | 1 0 | a Children with juvenile idiopathic arthritis frequently experience interruptions to their medical therapy |
| 264 | c 2014-02-12 | |
| 264 | 1 | b Wiley,c 2014 |
| 338 | a print2 rdacarrier | |
| 520 | a AimTo study real-life experiences of drug treatment discontinuations and safety in a well-defined cohort of patients with juvenile idiopathic arthritis (JIA), over an eleven-year period in Uppsala County, Sweden. MethodsClinical charts of all incident and prevalent cases of juvenile arthritis were reviewed prospectively by an experienced paediatric rheumatologist. Each patient file was supplemented retrospectively regarding hereditary diseases, clinical data and aspects of pharmacological treatment. ResultsSevere adverse events from methotrexate or biological agents were rare, but 84 occasions of interrupted therapy due to adverse events or inefficacy were identified within 225 treatment periods (37.3%) in the 156 patients (108 girls and 48 boys) studied. The median observation period was 8.6years after disease onset (minimum 1.33, maximum 17.5years). Oral and subcutaneous methotrexate caused adverse events in 22.6% of the treatment periods and biological agents in 19.2% (p=0.71). Discontinuation of treatment periods was equally common for methotrexate (38.7%) and biological agents (33.3%) (p=0.53). ConclusionOur study shows a high percentage of interrupted medical therapies, due to adverse events or inefficacy, in children with JIA. Adverse events from methotrexate and biological agents were seldom severe. The results highlight the need for better predictive factors to guide therapy. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng |
| 653 | a arthritis | |
| 653 | a juvenile | |
| 653 | a pharmacological | |
| 653 | a treatment | |
| 700 | 1 | a Holmquist, Larsu Uppsala universitet,Institutionen för kvinnors och barns hälsa4 aut |
| 700 | 1 | a Fagerlund, Andersu Uppsala universitet,Institutionen för kvinnors och barns hälsa4 aut |
| 700 | 1 | a Berntson, Lillemoru Uppsala universitet,Pediatrik4 aut0 (Swepub:uu)liber604 |
| 710 | 2 | a Uppsala universitetb Pediatrik4 org |
| 773 | 0 | t Acta Paediatricad : Wileyg 103:5, s. 529-536q 103:5<529-536x 0803-5253x 1651-2227 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-228031 |
| 856 | 4 8 | u https://doi.org/10.1111/apa.12556 |
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